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    IleRS Isoleucyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45785, updated on 10-May-2024

    Summary

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    Official Symbol
    IleRSprovided by FlyBase
    Official Full Name
    Isoleucyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027086
    Locus tag
    Dmel_CG11471
    See related
    AllianceGenome:FB:FBgn0027086
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aats-ile; CG11471; Dmel\CG11471; IARS; IRS; IsoleuRS; l(3)00827
    Summary
    Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including anterior endoderm; embryonic/larval muscle system; extended germ band embryo; gut section; and visceral muscle primordium. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See IleRS in Genome Data Viewer
    Location:
    79D4-79D4; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22288665..22292810)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22281765..22285910)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45960 Neighboring gene Serine-arginine protein kinase at 79D Neighboring gene HEM-protein Neighboring gene Tenascin major Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45963

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response. Nayak P, et al. Front Cell Dev Biol, 2021. PMID 34660574, Free PMC Article
    2. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
    3. The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis. Baumgartner S, et al. J Mol Biol, 1995 Aug 4. PMID 7643388
    4. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
    5. A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions. Slack C, et al. BMC Genet, 2006 Jun 2. PMID 16749923, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoleucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoleucine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isoleucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Isoleucyl-tRNA synthetase
    Names
    CG11471-PA
    CG11471-PC
    CG11471-PD
    IleRS-PA
    IleRS-PC
    IleRS-PD
    NP_524840.2
    NP_730716.1
    NP_788565.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22288665..22292810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168952.4 → NP_730716.1  Isoleucyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSW0
      Related
      FBpp0078150
      Conserved Domains (3) summary
      cd07961
      Location:650 → 847
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:373 → 650
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:9 → 1094
      PLN02882; aminoacyl-tRNA ligase

    2. NM_176387.2 → NP_788565.1  Isoleucyl-tRNA synthetase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSW0
      Related
      FBpp0078152
      Conserved Domains (3) summary
      cd07961
      Location:650 → 847
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:373 → 650
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:9 → 1094
      PLN02882; aminoacyl-tRNA ligase

    3. NM_080101.4 → NP_524840.2  Isoleucyl-tRNA synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524840.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSW0
      Related
      FBpp0078151
      Conserved Domains (3) summary
      cd07961
      Location:650 → 847
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:373 → 650
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:9 → 1094
      PLN02882; aminoacyl-tRNA ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSW0 Q8MSW0

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