Tspan10 tetraspanin 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tspan10provided by MGI
Official Full Name: tetraspanin 10provided by MGI
Primary source: MGI:MGI:2384781
See related: Ensembl:ENSMUSG00000039691 AllianceGenome:MGI:2384781
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ocsp
Summary: Enables enzyme binding activity. Involved in protein maturation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human TSPAN10 (tetraspanin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 5.3), spleen adult (RPKM 3.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.13 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120333457..120338147)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120442631..120447321)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tspan-5 and Tspan-10, are up-regulated during osteoclast differentiation and knockdown of their expression dramatically inhibits osteoclastogenesis
Title: Downregulation of Notch modulators, tetraspanin 5 and 10, inhibits osteoclastogenesis in vitro.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in establishment of protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tetraspanin-10

Names: oculospanin; tspan-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145363.2 → NP_663338.2 tetraspanin-10

See identical proteins and their annotated locations for NP_663338.2

Status: VALIDATED

Source sequence(s)

AK148326, BY479111, CK625019

Consensus CDS

CCDS25733.2

UniProtKB/Swiss-Prot

Q8VCF5

UniProtKB/TrEMBL

Q3UFS7, Q3UGA5

Related

ENSMUSP00000041883.9, ENSMUST00000044105.9

Conserved Domains (2) summary

cd03167
Location:171 → 290

oculospanin_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:74 → 304

Tetraspannin; Tetraspanin family