plrg1 pleiotropic regulator 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plrg1provided by ZNC
Official Full Name: pleiotropic regulator 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2787
See related: Ensembl:ENSDARG00000037283 AllianceGenome:ZFIN:ZDB-GENE-040426-2787
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55651; zgc:86603; wu:fi74f01
Summary: Acts upstream of or within negative regulation of DNA damage response, signal transduction by p53 class mediator and negative regulation of apoptotic process. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex; Prp19 complex; and catalytic step 2 spliceosome. Orthologous to human PLRG1 (pleiotropic regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (25650960..25666601)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (24960131..24975772)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLRG1 is a critical nuclear regulator of p53-dependent cell cycle progression and apoptosis during both embryonic development and adult tissue homeostasis.
Title: PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA damage response, signal transduction by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Prp19 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pleiotropic regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213440.1 → NP_998605.1 pleiotropic regulator 1

See identical proteins and their annotated locations for NP_998605.1

Status: PROVISIONAL

Source sequence(s)

AY648817

UniProtKB/TrEMBL

Q6DRE2

Related

ENSDARP00000054234.5, ENSDART00000054235.7

Conserved Domains (3) summary

COG2319
Location:190 → 504

WD40; WD40 repeat [General function prediction only]

cd00200
Location:193 → 487

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:206 → 241

7WD40; WD40 repeat [structural motif]