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    tyms thymidylate synthetase [ Danio rerio (zebrafish) ]

    Gene ID: 81540, updated on 27-Mar-2024

    Summary

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    Official Symbol
    tymsprovided by ZNC
    Official Full Name
    thymidylate synthetaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-59
    See related
    Ensembl:ENSDARG00000042894 AllianceGenome:ZFIN:ZDB-GENE-040426-59
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56465; zgc:77659
    Summary
    Enables thymidylate synthase activity. Acts upstream of or within dTMP biosynthetic process and retina development in camera-type eye. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including anterior neural tube; blood; nervous system; optic vesicle; and ventral mesoderm. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See tyms in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71535053..71541333)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71293912..71300192)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene alkaline ceramidase 2 Neighboring gene adenylate cyclase activating polypeptide 1a Neighboring gene methyltransferase 4, N6-adenosine

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos. Zhang Y, et al. PLoS One, 2010 May 12. PMID 20485548, Free PMC Article
    2. Sequence analysis and functional study of thymidylate synthase from zebrafish, Danio rerio. Du C, et al. J Biochem, 2006 May. PMID 16751599
    3. Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders. Frisk JH, et al. BMC Neurosci, 2022 Mar 27. PMID 35346037, Free PMC Article
    4. Dose- and time-dependent expression patterns of zebrafish orthologs of selected E2F target genes in response to serum starvation/replenishment. Sucularli C, et al. Mol Biol Rep, 2011 Aug. PMID 21116857
    5. Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Loponte S, et al. Sci Rep, 2016 Jul 26. PMID 27458029, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study revealed a structural requirement for the interaction of TS RNA with TS protein.
      Title: Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 5,10-methylenetetrahydrofolate-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidylate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidylate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymidylate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring one-carbon groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dTMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dTMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dTMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thymidylate synthase
    NP_571835.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131760.2 → NP_571835.2  thymidylate synthase

      Status: VALIDATED

      Source sequence(s)
      EH577904, EH580067, FP016237
      UniProtKB/TrEMBL
      A0A8M1P903, Q6P045
      Related
      ENSDARP00000047068.6, ENSDART00000047069.7
      Conserved Domains (1) summary
      pfam00303
      Location:38 → 318
      Thymidylat_synt; Thymidylate synthase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      71535053..71541333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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