Ifi203 interferon activated gene 203 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifi203provided by MGI
Official Full Name: interferon activated gene 203provided by MGI
Primary source: MGI:MGI:96428
See related: Ensembl:ENSMUSG00000039997 AllianceGenome:MGI:96428
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mndal; Ifi203a; Ifi203b
Summary: Predicted to enable double-stranded DNA binding activity. Acts upstream of or within cellular response to interferon-beta. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 5.0), mammary gland adult (RPKM 4.3) and 18 other tissues See more
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Genomic context

Location:: 1 H3; 1 80.76 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (173747966..173770432, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (173920400..173942866, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.
Title: Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.
analysis of p203 proteins that are expressed in the liver and down-regulated during liver regeneration
Title: Multiple splicing results in at least two p203 proteins that are expressed in the liver and down-regulated during liver regeneration.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-activable protein 203

Names: interferon-inducible protein p203

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302649.1 → NP_001289578.1 interferon-activable protein 203 isoform 1

See identical proteins and their annotated locations for NP_001289578.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC170584, AK040214, AK137616, AK144663, BE691222

Consensus CDS

CCDS78754.1

UniProtKB/TrEMBL

A0A1Z3MHZ5, E9QAN9

Related

ENSMUSP00000122424.2, ENSMUST00000129829.8

Conserved Domains (2) summary

cd08305
Location:10 → 83

Pyrin; a protein-protein interaction domain

pfam02760
Location:665 → 831

HIN; HIN-200/IF120x domain
NM_001302650.1 → NP_001289579.1 interferon-activable protein 203 isoform 2

See identical proteins and their annotated locations for NP_001289579.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AK144663, BE691222

Consensus CDS

CCDS48453.1

UniProtKB/Swiss-Prot

O35368, Q3T9I1, Q3TEA2, Q3TP57, Q3UMV2, Q8BYE5, Q91VV8

UniProtKB/TrEMBL

A0A0R4J0H6

Related

ENSMUSP00000114221.2, ENSMUST00000156895.8

Conserved Domains (2) summary

cd08305
Location:10 → 83

Pyrin; a protein-protein interaction domain

pfam02760
Location:251 → 417

HIN; HIN-200/IF120x domain
NM_001302651.1 → NP_001289580.1 interferon-activable protein 203 isoform 3

See identical proteins and their annotated locations for NP_001289580.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two in-frame exons in the coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK040214, AK144663, BE691222

Consensus CDS

CCDS35793.1

UniProtKB/Swiss-Prot

O35368, Q3T9I1, Q3TEA2, Q3TP57, Q3UMV2, Q8BYE5, Q91VV8

UniProtKB/TrEMBL

E9PUG6

Related

ENSMUSP00000121480.2, ENSMUST00000123708.8

Conserved Domains (2) summary

cd08305
Location:10 → 83

Pyrin; a protein-protein interaction domain

pfam02760
Location:203 → 369

HIN; HIN-200/IF120x domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

173747966..173770432 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250226.1 → XP_030106086.1 interferon-activable protein 203 isoform X5

Conserved Domains (1) summary

pfam02760
Location:377 → 543

HIN; HIN-200/IF120x domain
XM_030250260.1 → XP_030106120.1 interferon-activable protein 203 isoform X7

UniProtKB/Swiss-Prot

O35368, Q3T9I1, Q3TEA2, Q3TP57, Q3UMV2, Q8BYE5, Q91VV8

UniProtKB/TrEMBL

E9PUG6

Conserved Domains (2) summary

cd08305
Location:10 → 83

Pyrin; a protein-protein interaction domain

pfam02760
Location:203 → 369

HIN; HIN-200/IF120x domain
XM_011238761.4 → XP_011237063.1 interferon-activable protein 203 isoform X1

See identical proteins and their annotated locations for XP_011237063.1

UniProtKB/TrEMBL

A0A1Z3MHZ5

Conserved Domains (2) summary

cd08305
Location:10 → 83

Pyrin; a protein-protein interaction domain

pfam02760
Location:677 → 843

HIN; HIN-200/IF120x domain
XM_011238760.3 → XP_011237062.1 interferon-activable protein 203 isoform X1

See identical proteins and their annotated locations for XP_011237062.1

UniProtKB/TrEMBL

A0A1Z3MHZ5

Conserved Domains (2) summary

cd08305
Location:10 → 83

Pyrin; a protein-protein interaction domain

pfam02760
Location:677 → 843

HIN; HIN-200/IF120x domain
XM_036162001.1 → XP_036017894.1 interferon-activable protein 203 isoform X6

Conserved Domains (1) summary

pfam02760
Location:365 → 531

HIN; HIN-200/IF120x domain
XM_006496669.4 → XP_006496732.1 interferon-activable protein 203 isoform X3

Conserved Domains (2) summary

cd08305
Location:10 → 83

Pyrin; a protein-protein interaction domain

pfam02760
Location:629 → 795

HIN; HIN-200/IF120x domain
XM_011238762.3 → XP_011237064.1 interferon-activable protein 203 isoform X2

See identical proteins and their annotated locations for XP_011237064.1

UniProtKB/TrEMBL

A0A1Z3MHZ5, E9QAN9

Conserved Domains (2) summary

cd08305
Location:10 → 83

Pyrin; a protein-protein interaction domain

pfam02760
Location:665 → 831

HIN; HIN-200/IF120x domain
XM_006496671.5 → XP_006496734.1 interferon-activable protein 203 isoform X4

Conserved Domains (1) summary

pfam02760
Location:485 → 651

HIN; HIN-200/IF120x domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001045481.1: Suppressed sequence

Description

NM_001045481.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
NM_008328.2: Suppressed sequence

Description

NM_008328.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.