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    Amy2a5 amylase 2a5 [ Mus musculus (house mouse) ]

    Gene ID: 109959, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Amy2a5provided by MGI
    Official Full Name
    amylase 2a5provided by MGI
    Primary source
    MGI:MGI:88020
    See related
    Ensembl:ENSMUSG00000074268 AllianceGenome:MGI:88020
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Amy2; Amy-2; mAmy2-2; 1810008N23Rik
    Summary
    Enables amylase activity. Located in extracellular space. Orthologous to human AMY1B (amylase alpha 1B); AMY2A (amylase alpha 2A); and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 1235.2), small intestine adult (RPKM 952.2) and 2 other tissues See more
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    Genomic context

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    See Amy2a5 in Genome Data Viewer
    Location:
    3 F3; 3 49.35 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (113156494..113166015, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (113249178..113258699, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene amylase 2b Neighboring gene amylase 2, pseudogene 1 Neighboring gene amylase 2a4 Neighboring gene amylase 2a3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone. Slater EP, et al. Mol Endocrinol, 1993 Jul. PMID 8413315
    2. Report of the Committee on the Genetic Constitution of Chromosome 1. Hamerton JL, et al. Cytogenet Cell Genet, 1984. PMID 6360562
    3. Differential proteomic shotgun analysis elucidates involvement of water channel aquaporin 8 in presence of α-amylase in the colon. Magdeldin S, et al. J Proteome Res, 2010 Dec 3. PMID 20939500
    4. An insulin-responsive element in the pancreatic enhancer of the amylase gene. Johnson TM, et al. J Biol Chem, 1993 Jan 5. PMID 7678001
    5. Characterization of the amino termini of mouse salivary and pancreatic amylases. Karn RC, et al. FEBS Lett, 1981 Apr 20. PMID 6165618

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies confirmed the involvement of AQP8 in alpha-amylase 2 regulation.
      Title: Differential proteomic shotgun analysis elucidates involvement of water channel aquaporin 8 in presence of α-amylase in the colon.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107496, MGC118682

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-amylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pancreatic alpha-amylase 2a5
    Names
    1,4-alpha-D-glucan glucanohydrolase
    PA
    amylase 2, pancreatic
    amylase 2a5, pancreatic
    pancreatic alpha-amylase
    NP_001036176.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042711.2 → NP_001036176.1  pancreatic alpha-amylase 2a5 precursor

      See identical proteins and their annotated locations for NP_001036176.1

      Status: PROVISIONAL

      Source sequence(s)
      AK133526
      Consensus CDS
      CCDS17775.1
      UniProtKB/Swiss-Prot
      P00688, Q4VBW6, Q61295, Q61296, Q64301
      Related
      ENSMUSP00000096270.4, ENSMUST00000098673.5
      Conserved Domains (3) summary
      cd11317
      Location:25 → 413
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:420 → 507
      Aamy_C; Aamy_C domain
      COG0366
      Location:46 → 344
      AmyA; Glycosidase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      113156494..113166015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00688.2 GenPept UniProtKB/Swiss-Prot:P00688

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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