Ticrr TOPBP1-interacting checkpoint and replication regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ticrrprovided by MGI
Official Full Name: TOPBP1-interacting checkpoint and replication regulatorprovided by MGI
Primary source: MGI:MGI:1924261
See related: Ensembl:ENSMUSG00000046591 AllianceGenome:MGI:1924261
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lrrk1; 5730590G19Rik
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in DNA replication; mitotic G2/M transition checkpoint; and regulation of DNA-dependent DNA replication initiation. Predicted to act upstream of or within DNA repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain ventricular layer and inferior colliculus. Orthologous to human TICRR (TOPBP1 interacting checkpoint and replication regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 4.1), thymus adult (RPKM 2.9) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D2; 7 45.09 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (79309944..79347896)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (79660196..79698148)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)

General gene information

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Markers

5730590G19Rik (e-PCR), detects polymorphism
- UniSTS:527226

NoName (e-PCR)
- UniSTS:235694

D7Mit181 (e-PCR), detects polymorphism
- UniSTS:131071

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2 DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: treslin

Names: leucine-rich repeat kinase 1; topBP1-interacting, replication-stimulating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029835.1 → NP_084111.1 treslin

See identical proteins and their annotated locations for NP_084111.1

Status: VALIDATED

Source sequence(s)

AK033104, AK041726, AK051639, BC028450, BC058634, BY731867, CF730550, CN537331

Consensus CDS

CCDS21384.1

UniProtKB/Swiss-Prot

B2RY55, Q8BQ33, Q8C9N4, Q8CCI2

Related

ENSMUSP00000041377.8, ENSMUST00000035977.9

Conserved Domains (1) summary

pfam15292
Location:211 → 1005

Treslin_N; Treslin N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

79309944..79347896

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_173790.3: Suppressed sequence

Description

NM_173790.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.