unc119.2 unc-119 lipid binding chaperone B homolog 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: unc119.2provided by ZNC
Official Full Name: unc-119 lipid binding chaperone B homolog 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7635
See related: Ensembl:ENSDARG00000004459 AllianceGenome:ZFIN:ZDB-GENE-030131-7635
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zfUnc119c; wu:fk57d06; si:ch73-248e21.4
Summary: Predicted to enable lipid binding activity. Acts upstream of or within optomotor response and regulation of axon extension involved in axon guidance. Predicted to be active in intercellular bridge and microtubule cytoskeleton. Is expressed in epiphysis; eye photoreceptor cell; olfactory pit; otic vesicle; and retina. Used to study cone-rod dystrophy. Human ortholog(s) of this gene implicated in immunodeficiency 13. Orthologous to human UNC119 (unc-119 lipid binding chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (32615713..32619634)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (32483812..32487920)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unc119c, together with Arl3l1/2, plays an important role in modulating Wnt4a production and secretion during HC formation in the forebrain of the zebrafish embryo.
Title: Habenular commissure formation in zebrafish is regulated by the pineal gland-specific gene unc119c.

Submit: New GeneRIF Correction

General gene information

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Markers

fk57d06.x1 (e-PCR)
- UniSTS:201222

fj91b02.x1 (e-PCR)
- UniSTS:200299

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipoprotein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of caveolin-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within optomotor response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intercellular bridge	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein unc-119 homolog B

Names: unc-119 homolog 2; unc119c

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

32615713..32619634

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474294.1 → XP_021329969.1 protein unc-119 homolog B

UniProtKB/TrEMBL

A0A8M9PYI1, E7F2M1

Related

ENSDARP00000018950.8, ENSDART00000028010.10

Conserved Domains (1) summary

pfam05351
Location:98 → 250

GMP_PDE_delta; GMP-PDE, delta subunit

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394535.1 Reference GRCz11 ALT_DRER_TU_1

Range

102752..106611

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009299573.3 → XP_009297848.2 protein unc-119 homolog B

UniProtKB/TrEMBL

A0A8M3AR02

Conserved Domains (1) summary

pfam05351
Location:98 → 250

GMP_PDE_delta; GMP-PDE, delta subunit