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    cpsf2 cleavage and polyadenylation specific factor 2 [ Danio rerio (zebrafish) ]

    Gene ID: 436657, updated on 11-Apr-2024

    Summary

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    Official Symbol
    cpsf2provided by ZNC
    Official Full Name
    cleavage and polyadenylation specific factor 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-79
    See related
    Ensembl:ENSDARG00000028971 AllianceGenome:ZFIN:ZDB-GENE-040718-79
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92484
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage; mRNA polyadenylation; and pre-mRNA cleavage required for polyadenylation. Predicted to act upstream of or within mRNA cleavage and mRNA processing. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See cpsf2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (50052030..50086095)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (50249916..50283091)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene ribosomal oxygenase 1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Neighboring gene solute carrier family 24 member 4b Neighboring gene transmembrane protein 121Ab

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Bai X, et al. Cell, 2010 Jul 9. PMID 20603019, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cleavage and polyadenylation specificity factor subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002384.1 → NP_001002384.1  cleavage and polyadenylation specificity factor subunit 2

      See identical proteins and their annotated locations for NP_001002384.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076029
      UniProtKB/TrEMBL
      Q6DHE5
      Related
      ENSDARP00000047211.4, ENSDART00000047212.6
      Conserved Domains (5) summary
      smart01027
      Location:243 → 368
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:5 → 430
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:528 → 567
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      pfam13299
      Location:609 → 787
      CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
      cd16293
      Location:7 → 204
      CPSF2-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      50052030..50086095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352464.2 → XP_017207953.1  cleavage and polyadenylation specificity factor subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YWL8, F1QVV4
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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