Prss55 serine protease 55 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss55provided by MGI
Official Full Name: serine protease 55provided by MGI
Primary source: MGI:MGI:1918287
See related: Ensembl:ENSMUSG00000034623 AllianceGenome:MGI:1918287
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933401F05Rik
Summary: Predicted to enable serine-type endopeptidase activity. Involved in binding activity of sperm to zona pellucida and flagellated sperm motility. Located in acrosomal vesicle and plasma membrane. Orthologous to human PRSS55 (serine protease 55). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 127.8) See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 33.35 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (64312884..64338445, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (64075435..64085449, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice.
Title: PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice.
Prss55 but not Prss51 is required for male fertility in micedagger.
Title: Prss55 but not Prss51 is required for male fertility in mice†.
Study of the mouse Tex37 and Prss55 - genes evolutionarily conserved in eutherians (including human) found that these genes had a testis-enriched expression pattern in mice, but they are not individually essential for spermatogenesis, testis development and male fertility in mice in laboratory conditions.
Title: The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice.
Data show that serine protease 55 (PRSS55) plays vital roles in regulating male fertility including in vivo sperm migration and in vitro sperm-egg interaction
Title: Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm-egg binding.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IDA Inferred from Direct Assay more info	PubMed
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease 55

Names: probable serine protease UNQ9391/PRO34284 homolog; protease, serine 55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081063.2 → NP_001074532.1 serine protease 55 isoform 1 precursor

See identical proteins and their annotated locations for NP_001074532.1

Status: VALIDATED

Source sequence(s)

AC166997

Consensus CDS

CCDS36952.1

UniProtKB/Swiss-Prot

G3X9K6, Q14BX2

Related

ENSMUSP00000086752.6, ENSMUST00000089338.6

Conserved Domains (1) summary

smart00020
Location:34 → 261

Tryp_SPc; Trypsin-like serine protease
NM_001379522.1 → NP_001366451.1 serine protease 55 isoform 2

Status: VALIDATED

Source sequence(s)

AC166997

Conserved Domains (1) summary

smart00020
Location:50 → 277

Tryp_SPc; Trypsin-like serine protease
NM_001379523.1 → NP_001366452.1 serine protease 55 isoform 3

Status: VALIDATED

Source sequence(s)

AC166997

Conserved Domains (1) summary

smart00020
Location:33 → 260

Tryp_SPc; Trypsin-like serine protease

RNA

NR_166743.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC166997

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

64312884..64338445 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158848.1 → XP_036014741.1 serine protease 55 isoform X1

Conserved Domains (1) summary

smart00020
Location:60 → 287

Tryp_SPc; Trypsin-like serine protease
XM_017316194.3 → XP_017171683.1 serine protease 55 isoform X2

Conserved Domains (1) summary

smart00020
Location:34 → 272

Tryp_SPc; Trypsin-like serine protease
XM_030248023.1 → XP_030103883.1 serine protease 55 isoform X3

Conserved Domains (1) summary

smart00020
Location:33 → 271

Tryp_SPc; Trypsin-like serine protease
XM_030248026.1 → XP_030103886.1 serine protease 55 isoform X4

Conserved Domains (1) summary

cd00190
Location:1 → 157

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_030248025.1 → XP_030103885.1 serine protease 55 isoform X4

Conserved Domains (1) summary

cd00190
Location:1 → 157

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...