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    Msra methionine sulfoxide reductase A [ Mus musculus (house mouse) ]

    Gene ID: 110265, updated on 8-May-2024

    Summary

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    Official Symbol
    Msraprovided by MGI
    Official Full Name
    methionine sulfoxide reductase Aprovided by MGI
    Primary source
    MGI:MGI:106916
    See related
    Ensembl:ENSMUSG00000054733 AllianceGenome:MGI:106916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSR-A; 2310045J23Rik; 6530413P12Rik
    Summary
    Enables peptide-methionine (S)-S-oxide reductase activity. Predicted to be involved in aging and cellular response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including musculoskeletal system; nervous system; respiratory system; sensory organ; and testis. Orthologous to human MSRA (methionine sulfoxide reductase A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 18.2), liver adult (RPKM 8.4) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Msra in Genome Data Viewer
    Location:
    14 D1; 14 33.36 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (64360070..64693352, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (64122621..64455903, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930471C04 gene Neighboring gene RIKEN cDNA 9630015K15 gene Neighboring gene serine protease 55 Neighboring gene serine protease 52 Neighboring gene predicted gene, 53862 Neighboring gene predicted gene, 52129 Neighboring gene predicted gene, 52132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:64891141-64891294 Neighboring gene STARR-seq mESC enhancer starr_36937 Neighboring gene predicted gene, 41176 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:64942459-64942678 Neighboring gene predicted gene, 52131 Neighboring gene STARR-seq mESC enhancer starr_36939 Neighboring gene STARR-seq mESC enhancer starr_36940 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65053006-65053159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65059749-65059936 Neighboring gene predicted gene, 52130 Neighboring gene STARR-seq mESC enhancer starr_36941 Neighboring gene STARR-seq mESC enhancer starr_36942 Neighboring gene Mir124-1 host gene (non-protein coding) Neighboring gene microRNA 124a-1 Neighboring gene microRNA 3078

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lack of the antioxidant enzyme methionine sulfoxide reductase A in mice impairs RPE phagocytosis and causes photoreceptor cone dysfunction. Mazzoni F, et al. Redox Biol, 2021 Jun. PMID 33674251, Free PMC Article
    2. MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-κB Signaling Pathway. Fan H, et al. Drug Des Devel Ther, 2020. PMID 32308370, Free PMC Article
    3. Methionine Sulfoxide Reductase A Knockout Mice Show Progressive Hearing Loss and Sensitivity to Acoustic Trauma. Alqudah S, et al. Audiol Neurootol, 2018. PMID 29929200
    4. Methionine sulfoxide reductase A protects against lipopolysaccharide-induced septic shock via negative regulation of the proinflammatory responses. Singh MP, et al. Arch Biochem Biophys, 2017 Oct 1. PMID 28803836
    5. Methionine Sulfoxide Reductase A Deficiency Exacerbates Cisplatin-Induced Nephrotoxicity via Increased Mitochondrial Damage and Renal Cell Death. Noh MR, et al. Antioxid Redox Signal, 2017 Oct 10. PMID 28158949

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sexually dimorphic effects of methionine sulfoxide reductase A (MsrA) on murine longevity and health span during methionine restriction.
      Title: Sexually dimorphic effects of methionine sulfoxide reductase A (MsrA) on murine longevity and health span during methionine restriction.
    2. MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-kappaB Signaling Pathway.
      Title: MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-κB Signaling Pathway.
    3. It has been proposed that MsrA-dependent 14-3-3 zeta ubiquitination affects the regulation of alpha synuclein degradation and dopamine synthesis in the brain.
      Title: Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14-3-3 protein isotypes in brain.
    4. MsrA knockout mice showed an increased sensitivity to noise at young and older ages, suggesting that MsrA is part of a mechanism that protects the cochlea from acoustic damage. MsrA mRNA in the cochlea was increased following acoustic stimulation.
      Title: Methionine Sulfoxide Reductase A Knockout Mice Show Progressive Hearing Loss and Sensitivity to Acoustic Trauma.
    5. Our findings demonstrate that reversal of methionine oxidation is required for maintenance of cellular homeostasis in the absence of increased oxidative stress. These data provide the first link between autophagy and activation of Nrf2 in the setting of MsrA deletion
      Title: Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription.
    6. Study shows that cisplatin induces methionine oxidation, oxidative stress, mitochondrial damage, apoptosis, and necrosis, and that MsrA gene deletion accelerates these cisplatin-induced damages. This indicates that MsrA protects kidney against cisplatin-induced acute kidney injury.
      Title: Methionine Sulfoxide Reductase A Deficiency Exacerbates Cisplatin-Induced Nephrotoxicity via Increased Mitochondrial Damage and Renal Cell Death.
    7. MsrA protects against lipopolysaccharide-induced septic shock, and negatively regulates proinflammatory responses via inhibition of the ROS-MAPK-NF-kappaB signaling pathways.
      Title: Methionine sulfoxide reductase A protects against lipopolysaccharide-induced septic shock via negative regulation of the proinflammatory responses.
    8. Collectively, our results suggest that MsrA protects hepatocytes from APAP-induced cytotoxicity through the modulation of TXNRD1 expression.
      Title: Methionine sulfoxide reductase A protects hepatocytes against acetaminophen-induced toxicity via regulation of thioredoxin reductase 1 expression.
    9. results demonstrate that MsrA protects the liver from APAP-induced toxicity. The data provided herein constitute the first in vivo evidence of the involvement of MsrA in hepatic function under APAP challenge
      Title: Methionine sulfoxide reductase A deficiency exacerbates acute liver injury induced by acetaminophen.
    10. Results suggest that lower MsrA activity modifies Amyloid-beta solubility properties and causes mitochondrial dysfunction in a mouse model of Alzheimer's disease.
      Title: Methionine sulfoxide reductase A affects β-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101976

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-methionine-(S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-methionine (S)-S-oxide reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptide-methionine (S)-S-oxide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial peptide methionine sulfoxide reductase
    Names
    PMSR
    peptide Met(O) reductase
    peptide methionine sulfoxide reductase
    peptide-methionine (S)-S-oxide reductase
    protein-methionine-S-oxide reductase
    NP_001240641.1
    NP_001240643.1
    NP_001240644.1
    NP_001240645.1
    NP_001334568.1
    NP_080598.2
    XP_011243223.1
    XP_030103466.1
    XP_030103467.1
    XP_030103468.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253712.1 → NP_001240641.1  mitochondrial peptide methionine sulfoxide reductase isoform 1

      See identical proteins and their annotated locations for NP_001240641.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK049714, CX200370
      Consensus CDS
      CCDS27209.1
      UniProtKB/Swiss-Prot
      Q5EBQ7, Q91WK9, Q9D6Y7, Q9DCY2
      Conserved Domains (1) summary
      PRK00058
      Location:26 → 228
      PRK00058; peptide-methionine (S)-S-oxide reductase MsrA

    2. NM_001253714.1 → NP_001240643.1  mitochondrial peptide methionine sulfoxide reductase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon and encodes a shorter isoform (2), compared to variant 1.
      Source sequence(s)
      BB652761, BC089311, CB953198, CX200370
      UniProtKB/Swiss-Prot
      Q9D6Y7
      Conserved Domains (1) summary
      PRK00058
      Location:26 → 205
      PRK00058; methionine sulfoxide reductase A; Provisional

    3. NM_001253715.1 → NP_001240644.1  mitochondrial peptide methionine sulfoxide reductase isoform 3

      See identical proteins and their annotated locations for NP_001240644.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame coding exon and encodes a shorter isoform (3), compared to variant 1.
      Source sequence(s)
      AC134898, AC154332, AC166997
      UniProtKB/Swiss-Prot
      Q9D6Y7
      Conserved Domains (1) summary
      cl00366
      Location:26 → 188
      PMSR; Peptide methionine sulfoxide reductase

    4. NM_001253716.1 → NP_001240645.1  mitochondrial peptide methionine sulfoxide reductase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK018338, BC089311, BY282106, CX200370
      Consensus CDS
      CCDS84147.1
      UniProtKB/Swiss-Prot
      Q9D6Y7
      Related
      ENSMUSP00000147689.2, ENSMUST00000210428.2
      Conserved Domains (1) summary
      PRK00058
      Location:4 → 186
      PRK00058; methionine sulfoxide reductase A; Provisional

    5. NM_001347639.1 → NP_001334568.1  mitochondrial peptide methionine sulfoxide reductase isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (5) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA270013, CA323822, CD776038
      Consensus CDS
      CCDS84146.1
      UniProtKB/TrEMBL
      A0A1B0GT40
      Related
      ENSMUSP00000148189.2, ENSMUST00000210363.2

    6. NM_026322.4 → NP_080598.2  mitochondrial peptide methionine sulfoxide reductase isoform 1

      See identical proteins and their annotated locations for NP_080598.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC089311, CX200370
      Consensus CDS
      CCDS27209.1
      UniProtKB/Swiss-Prot
      Q5EBQ7, Q91WK9, Q9D6Y7, Q9DCY2
      Related
      ENSMUSP00000065754.8, ENSMUST00000067927.9
      Conserved Domains (1) summary
      PRK00058
      Location:26 → 228
      PRK00058; peptide-methionine (S)-S-oxide reductase MsrA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      64360070..64693352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247606.1 → XP_030103466.1  mitochondrial peptide methionine sulfoxide reductase isoform X1

      UniProtKB/Swiss-Prot
      Q5EBQ7, Q91WK9, Q9D6Y7, Q9DCY2
      Conserved Domains (1) summary
      PRK00058
      Location:26 → 228
      PRK00058; peptide-methionine (S)-S-oxide reductase MsrA

    2. XM_030247608.1 → XP_030103468.1  mitochondrial peptide methionine sulfoxide reductase isoform X4

      Conserved Domains (1) summary
      cl00366
      Location:4 → 146
      PMSR; Peptide methionine sulfoxide reductase

    3. XM_011244921.4 → XP_011243223.1  mitochondrial peptide methionine sulfoxide reductase isoform X2

      Conserved Domains (1) summary
      PRK00058
      Location:5 → 191
      PRK00058; peptide-methionine (S)-S-oxide reductase MsrA

    4. XM_030247607.1 → XP_030103467.1  mitochondrial peptide methionine sulfoxide reductase isoform X3

      Conserved Domains (1) summary
      cl00366
      Location:6 → 124
      PMSR; Peptide methionine sulfoxide reductase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6Y7.1 GenPept UniProtKB/Swiss-Prot:Q9D6Y7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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