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    Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140728, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cacng7provided by RGD
    Official Full Name
    calcium voltage-gated channel auxiliary subunit gamma 7provided by RGD
    Primary source
    RGD:628807
    See related
    Ensembl:ENSRNOG00000056257 AllianceGenome:RGD:628807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium channel regulator activity and voltage-gated calcium channel activity. Involved in positive regulation of dendrite extension; regulation of AMPA receptor activity; and regulation of mRNA stability. Located in cerebellar mossy fiber; early endosome; and neuronal cell body. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Orthologous to human CACNG7 (calcium voltage-gated channel auxiliary subunit gamma 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 67.8), Muscle (RPKM 6.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cacng7 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74715483..74746669, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65800059..65831246, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64374547..64405380, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 6 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 8 Neighboring gene microRNA 935 Neighboring gene uncharacterized LOC103691003 Neighboring gene protein kinase C, gamma Neighboring gene myeloid-associated differentiation marker

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stargazin-related protein γ₇ is associated with signalling endosomes in superior cervical ganglion neurons and modulates neurite outgrowth. Waithe D, et al. J Cell Sci, 2011 Jun 15. PMID 21610096, Free PMC Article
    2. The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2. Ferron L, et al. J Neurosci, 2008 Oct 15. PMID 18923037, Free PMC Article
    3. TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs. Studniarczyk D, et al. Nat Neurosci, 2013 Sep. PMID 23872597, Free PMC Article
    4. Distribution of transmembrane AMPA receptor regulatory protein (TARP) isoforms in the rat spinal cord. Larsson M, et al. Neuroscience, 2013 Sep 17. PMID 23751177
    5. New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. Kato AS, et al. J Neurosci, 2007 May 2. PMID 17475805, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of AMPA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmission of nerve impulse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of L-type voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of L-type voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cerebellar mossy fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-dependent calcium channel gamma-7 subunit
    Names
    TARP gamma-7
    calcium channel, voltage-dependent, gamma subunit 7
    neuronal voltage-gated calcium channel gamma-7 subunit
    transmembrane AMPAR regulatory protein gamma-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080695.2 → NP_542426.1  voltage-dependent calcium channel gamma-7 subunit

      See identical proteins and their annotated locations for NP_542426.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P62957
      UniProtKB/TrEMBL
      A6KS40
      Related
      ENSRNOP00000069074.1, ENSRNOT00000089944.2
      Conserved Domains (1) summary
      cl21598
      Location:16 → 195
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      74715483..74746669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082037.2 → XP_038937965.1  voltage-dependent calcium channel gamma-7 subunit isoform X1

      Conserved Domains (1) summary
      cl21598
      Location:18 → 142
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62957.1 GenPept UniProtKB/Swiss-Prot:P62957

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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