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    Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140727, updated on 13-Apr-2024

    Summary

    Official Symbol
    Cacng6provided by RGD
    Official Full Name
    calcium voltage-gated channel auxiliary subunit gamma 6provided by RGD
    Primary source
    RGD:628806
    See related
    Ensembl:ENSRNOG00000063051 AllianceGenome:RGD:628806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium channel regulator activity. Predicted to be involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to be part of L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease. Orthologous to human CACNG6 (calcium voltage-gated channel auxiliary subunit gamma 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 160.4) and Heart (RPKM 25.5) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cacng6 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74648342..74663351, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65732910..65747377, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64307684..64322124, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 Neighboring gene V-set and transmembrane domain containing 1 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 8 Neighboring gene microRNA 935 Neighboring gene uncharacterized LOC103691003 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of L-type voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of L-type voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of L-type voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    voltage-dependent calcium channel gamma-6 subunit
    Names
    calcium channel, voltage-dependent, gamma subunit 6
    neuronal voltage-gated calcium channel gamma-6 subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080694.2NP_542425.1  voltage-dependent calcium channel gamma-6 subunit

      See identical proteins and their annotated locations for NP_542425.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q8VHW6, Q8VHW7
      UniProtKB/TrEMBL
      A6KS37
      Related
      ENSRNOP00000095459.1, ENSRNOT00000111328.1
      Conserved Domains (1) summary
      cl21598
      Location:47223
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      74648342..74663351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008758749.3XP_008756971.1  voltage-dependent calcium channel gamma-6 subunit isoform X1

      See identical proteins and their annotated locations for XP_008756971.1

      UniProtKB/TrEMBL
      A6KS36
      Related
      ENSRNOP00000092698.1
      Conserved Domains (1) summary
      cl21598
      Location:47141
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family