Pwp1 PWP1 homolog, endonuclein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pwp1provided by MGI
Official Full Name: PWP1 homolog, endonucleinprovided by MGI
Primary source: MGI:MGI:1914735
See related: Ensembl:ENSMUSG00000001785 AllianceGenome:MGI:1914735
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310058A11Rik; 2610205J09Rik
Summary: Enables H4K20me3 modified histone binding activity. Acts upstream of or within histone H4-K20 trimethylation; negative regulation of peptidyl-serine phosphorylation of STAT protein; and positive regulation of stem cell differentiation. Located in nucleus. Is expressed in several structures, including brain; neural retina; and trachea. Orthologous to human PWP1 (PWP1 homolog, endonuclein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 17.4), CNS E18 (RPKM 12.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 41.73 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (85707695..85724967)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (85871831..85889103)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors found that the level of Pwp1 in mESCs is much higher than that in mouse embryonic fibroblasts (MEFs) and Pwp1 KD critically affects the conversion of mESCs from pluripotency to differentiation.
Title: Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV083409 (e-PCR)
- UniSTS:165716

AI098170 (e-PCR)
- UniSTS:163483

RH125438 (e-PCR)
- UniSTS:162259

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables H4K20me3 modified histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone chaperone activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: periodic tryptophan protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133993.3 → NP_598754.2 periodic tryptophan protein 1 homolog

See identical proteins and their annotated locations for NP_598754.2

Status: VALIDATED

Source sequence(s)

AK082158, BB032128, BY771053

Consensus CDS

CCDS24092.1

UniProtKB/Swiss-Prot

Q99LL5, Q9D6T6

Related

ENSMUSP00000001836.3, ENSMUST00000001836.11

Conserved Domains (3) summary

COG2319
Location:252 → 493

WD40; WD40 repeat [General function prediction only]

sd00039
Location:258 → 295

7WD40; WD40 repeat [structural motif]

cl02567
Location:252 → 413

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...