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    Triml1 tripartite motif family-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 244448, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Triml1provided by MGI
    Official Full Name
    tripartite motif family-like 1provided by MGI
    Primary source
    MGI:MGI:2687279
    See related
    Ensembl:ENSMUSG00000031651 AllianceGenome:MGI:2687279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933403D14
    Summary
    Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and regulation of viral entry into host cell. Predicted to be active in cytosol and nucleoplasm. Is expressed in early conceptus and testis. Orthologous to human TRIML1 (tripartite motif family like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 5.7) See more
    Orthologs
    human all
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    Genomic context

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    See Triml1 in Genome Data Viewer
    Location:
    8 A4; 8 23.89 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (43582843..43633531, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43129806..43180494, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21308 Neighboring gene predicted gene, 26181 Neighboring gene tryptophanyl-tRNA synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21309 Neighboring gene STARR-seq mESC enhancer starr_21310 Neighboring gene STARR-seq mESC enhancer starr_21312 Neighboring gene STARR-seq mESC enhancer starr_21313 Neighboring gene STARR-seq mESC enhancer starr_21314 Neighboring gene STARR-seq mESC enhancer starr_21316 Neighboring gene bromodomain adjacent to zinc finger domain, 2A pseudogene Neighboring gene tripartite motif family-like 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21317 Neighboring gene STARR-seq mESC enhancer starr_21318 Neighboring gene STARR-seq mESC enhancer starr_21319 Neighboring gene STARR-seq mESC enhancer starr_21325 Neighboring gene zinc finger protein 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1. Tian L, et al. Mol Reprod Dev, 2009 Jul. PMID 19156909
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterized TRIML1, which expresses in embryo before implantation; binding partner of TRIML1, Ubiquitin-specific protease 5 (USP5), was identified
      Title: Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase TRIML1
    Names
    RING-type E3 ubiquitin transferase TRIML1
    tripartite motif family-like protein 1
    NP_808410.1
    XP_006509485.1
    XP_011240521.1
    XP_011240524.1
    XP_017168289.1
    XP_017168290.1
    XP_017168291.1
    XP_017168292.1
    XP_017168293.1
    XP_017168294.1
    XP_017168295.1
    XP_017168297.1
    XP_017168298.1
    XP_017168299.1
    XP_030099397.1
    XP_030099398.1
    XP_030099399.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177742.4 → NP_808410.1  probable E3 ubiquitin-protein ligase TRIML1

      See identical proteins and their annotated locations for NP_808410.1

      Status: VALIDATED

      Source sequence(s)
      AK077092
      Consensus CDS
      CCDS22266.1
      UniProtKB/Swiss-Prot
      Q8BVP1
      UniProtKB/TrEMBL
      B2RUL3
      Related
      ENSMUSP00000050267.4, ENSMUST00000059692.4
      Conserved Domains (2) summary
      pfam15227
      Location:22 → 62
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd13733
      Location:293 → 468
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      43582843..43633531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312805.2 → XP_017168294.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

      Conserved Domains (1) summary
      cd13733
      Location:150 → 325
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    2. XM_017312810.1 → XP_017168299.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

      Conserved Domains (1) summary
      cd13733
      Location:150 → 325
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    3. XM_017312809.1 → XP_017168298.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

      Conserved Domains (1) summary
      cd13733
      Location:150 → 325
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    4. XM_017312804.1 → XP_017168293.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

      Conserved Domains (1) summary
      cd13733
      Location:150 → 325
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    5. XM_017312806.1 → XP_017168295.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

      Conserved Domains (1) summary
      cd13733
      Location:150 → 325
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    6. XM_017312808.1 → XP_017168297.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

      Conserved Domains (1) summary
      cd13733
      Location:150 → 325
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    7. XM_017312803.1 → XP_017168292.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X7

      UniProtKB/TrEMBL
      B2RUL3
      Conserved Domains (3) summary
      TIGR00599
      Location:20 → 161
      rad18; DNA repair protein rad18
      cd13733
      Location:242 → 417
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cd16590
      Location:19 → 63
      RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

    8. XM_017312801.1 → XP_017168290.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

      UniProtKB/TrEMBL
      B2RUL3
      Conserved Domains (3) summary
      TIGR00599
      Location:20 → 161
      rad18; DNA repair protein rad18
      cd13733
      Location:319 → 494
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cd16590
      Location:19 → 63
      RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

    9. XM_011242219.2 → XP_011240521.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X3

      UniProtKB/TrEMBL
      B7ZNZ0
      Conserved Domains (3) summary
      TIGR00599
      Location:20 → 161
      rad18; DNA repair protein rad18
      cd13733
      Location:319 → 494
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cd16590
      Location:19 → 63
      RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

    10. XM_017312800.1 → XP_017168289.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X1

      UniProtKB/TrEMBL
      B7ZNZ0
      Conserved Domains (3) summary
      TIGR00599
      Location:20 → 161
      rad18; DNA repair protein rad18
      cd13733
      Location:320 → 495
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cd16590
      Location:19 → 63
      RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

    11. XM_030243537.1 → XP_030099397.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X6

      UniProtKB/TrEMBL
      B2RUL3
      Conserved Domains (3) summary
      TIGR00599
      Location:20 → 161
      rad18; DNA repair protein rad18
      cd13733
      Location:292 → 467
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cd16590
      Location:19 → 63
      RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

    12. XM_017312802.1 → XP_017168291.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X5

      UniProtKB/TrEMBL
      B7ZNZ0
      Conserved Domains (3) summary
      TIGR00599
      Location:20 → 161
      rad18; DNA repair protein rad18
      cd13733
      Location:293 → 468
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cd16590
      Location:19 → 63
      RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

    13. XM_011242222.2 → XP_011240524.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X10

      Conserved Domains (1) summary
      cd13733
      Location:123 → 298
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    14. XM_030243539.1 → XP_030099399.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X10

      Conserved Domains (1) summary
      cd13733
      Location:123 → 298
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    15. XM_030243538.1 → XP_030099398.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X9

      Conserved Domains (1) summary
      cd13733
      Location:124 → 299
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    16. XM_006509422.4 → XP_006509485.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X4

      UniProtKB/TrEMBL
      B7ZNZ0
      Conserved Domains (3) summary
      TIGR00599
      Location:20 → 161
      rad18; DNA repair protein rad18
      cd13733
      Location:294 → 469
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cd16590
      Location:19 → 63
      RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

    RNA

    1. XR_003947277.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVP1.1 GenPept UniProtKB/Swiss-Prot:Q8BVP1

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