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    Shf Src homology 2 domain containing F [ Mus musculus (house mouse) ]

    Gene ID: 435684, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Shfprovided by MGI
    Official Full Name
    Src homology 2 domain containing Fprovided by MGI
    Primary source
    MGI:MGI:3613669
    See related
    Ensembl:ENSMUSG00000033256 AllianceGenome:MGI:3613669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Predicted to act upstream of or within apoptotic process. Is expressed in several structures, including endocrine gland; large intestine; male reproductive gland or organ; nervous system; and trachea. Orthologous to human SHF (Src homology 2 domain containing F). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 11.0), whole brain E14.5 (RPKM 2.7) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Shf in Genome Data Viewer
    Location:
    2 E5; 2 60.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122179373..122199650, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122348892..122369147, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1 Neighboring gene STARR-seq mESC enhancer starr_05553 Neighboring gene STARR-positive B cell enhancer ABC_E10134 Neighboring gene STARR-seq mESC enhancer starr_05555 Neighboring gene STARR-positive B cell enhancer ABC_E1253 Neighboring gene STARR-positive B cell enhancer ABC_E7854 Neighboring gene nuclear encoded tRNA histidine 4 (anticodon GTG) Neighboring gene predicted gene, 39918 Neighboring gene nuclear encoded tRNA histidine 3 (anticodon GTG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease. Yamaguchi-Kabata Y, et al. Hum Genet, 2018 Jul. PMID 30006735, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results, obtained from the integrative approach, suggest that LBH and SHF are associated with the Alzheimer's disease pathogenesis.
      Title: Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing adapter protein F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013829.2 → NP_001013851.2  SH2 domain-containing adapter protein F isoform 2

      See identical proteins and their annotated locations for NP_001013851.2

      Status: VALIDATED

      Source sequence(s)
      AI413498, AL844566, CB056323, CX222912
      Consensus CDS
      CCDS16662.1
      UniProtKB/Swiss-Prot
      A2AQ90, A2AQ91, Q8CG80
      Related
      ENSMUSP00000106160.3, ENSMUST00000110531.9
      Conserved Domains (1) summary
      cd10392
      Location:136 → 233
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

    2. NM_001374011.1 → NP_001360940.1  SH2 domain-containing adapter protein F isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL844566
      UniProtKB/TrEMBL
      A2AQ87
      Related
      ENSMUSP00000117099.2, ENSMUST00000125826.8
      Conserved Domains (1) summary
      cd10392
      Location:381 → 478
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      122179373..122199650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162368.1 → XP_036018261.1  SH2 domain-containing adapter protein F isoform X1

      UniProtKB/TrEMBL
      A2AQ87
      Conserved Domains (1) summary
      cd10392
      Location:305 → 400
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

    2. XM_017319108.3 → XP_017174597.1  SH2 domain-containing adapter protein F isoform X2

      UniProtKB/TrEMBL
      A2AQ89
      Related
      ENSMUSP00000119980.2, ENSMUST00000139819.8
      Conserved Domains (2) summary
      cd10392
      Location:183 → 280
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
      PHA03247
      Location:8 → 179
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CG80.2 GenPept UniProtKB/Swiss-Prot:Q8CG80

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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