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    Lrrc4b leucine rich repeat containing 4B [ Mus musculus (house mouse) ]

    Gene ID: 272381, updated on 9-May-2024

    Summary

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    Official Symbol
    Lrrc4bprovided by MGI
    Official Full Name
    leucine rich repeat containing 4Bprovided by MGI
    Primary source
    MGI:MGI:3027390
    See related
    Ensembl:ENSMUSG00000047085 AllianceGenome:MGI:3027390
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ngl3; Lrig4; A830007M12
    Summary
    Enables signaling receptor binding activity. Involved in positive regulation of synapse assembly. Located in cerebellar mossy fiber. Is expressed in several structures, including branchial arch; central nervous system; heart; sensory organ; and sympathetic nervous system. Orthologous to human LRRC4B (leucine rich repeat containing 4B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 96.7), CNS E18 (RPKM 74.6) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc4b in Genome Data Viewer
    Location:
    7 B3; 7 28.83 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44091911..44112775)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44442487..44463351)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700008O03 gene Neighboring gene synaptotagmin III Neighboring gene STARR-positive B cell enhancer ABC_E4924 Neighboring gene STARR-seq mESC enhancer starr_18797 Neighboring gene predicted gene, 39002 Neighboring gene predicted gene, 39003 Neighboring gene STARR-positive B cell enhancer ABC_E9110 Neighboring gene aspartate dehydrogenase domain containing Neighboring gene microRNA 7052 Neighboring gene Josephin domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NGL-3-induced presynaptic differentiation of hippocampal neurons in an afadin-dependent, nectin-1-independent manner. Maruo T, et al. Genes Cells, 2017 Aug. PMID 28695613
    2. NGL-3 in the regulation of brain development, Akt/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors. Lee H, et al. PLoS Biol, 2019 Jun. PMID 31166939, Free PMC Article
    3. IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ. Yoshida T, et al. J Neurosci, 2011 Sep 21. PMID 21940441, Free PMC Article
    4. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Mandai K, et al. Neuron, 2009 Sep 10. PMID 19755105, Free PMC Article
    5. NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation. Kim S, et al. Nat Neurosci, 2006 Oct. PMID 16980967

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NGL-3 induced differentiation of hippocampal mossy fibers. This activity of NGL-3 was dependent on afadin, but not the afadin-binding presynaptic nectin-1.
      Title: NGL-3-induced presynaptic differentiation of hippocampal neurons in an afadin-dependent, nectin-1-independent manner.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic density assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic density assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cerebellar mossy fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 4B
    Names
    NGL-3
    leucine-rich repeats and immunoglobulin-like domains 4
    netrin-G3 ligand

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198250.1 → NP_937893.1  leucine-rich repeat-containing protein 4B precursor

      See identical proteins and their annotated locations for NP_937893.1

      Status: PROVISIONAL

      Source sequence(s)
      BC060263
      Consensus CDS
      CCDS21206.1
      UniProtKB/Swiss-Prot
      P0C192
      Related
      ENSMUSP00000053123.9, ENSMUST00000058667.15
      Conserved Domains (6) summary
      smart00013
      Location:59 → 92
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:313 → 363
      LRRCT; Leucine rich repeat C-terminal domain
      COG4886
      Location:89 → 299
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:90 → 113
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07679
      Location:366 → 455
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:366 → 369
      Ig; Ig strand A [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44091911..44112775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C192.1 GenPept UniProtKB/Swiss-Prot:P0C192

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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