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    Ccdc57 coiled-coil domain containing 57 [ Mus musculus (house mouse) ]

    Gene ID: 71276, updated on 7-May-2024

    Summary

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    Official Symbol
    Ccdc57provided by MGI
    Official Full Name
    coiled-coil domain containing 57provided by MGI
    Primary source
    MGI:MGI:1918526
    See related
    Ensembl:ENSMUSG00000048445 AllianceGenome:MGI:1918526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933434G05Rik
    Summary
    Involved in cilium assembly. Predicted to be located in centriolar satellite; centriole; and spindle microtubule. Orthologous to human CCDC57 (coiled-coil domain containing 57). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.0), ovary adult (RPKM 2.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc57 in Genome Data Viewer
    Location:
    11 E2; 11 84.59 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120717355..120823703, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120826529..120932926, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120657732-120657915 Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like Neighboring gene STARR-positive B cell enhancer ABC_E9039 Neighboring gene fatty acid synthase Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene RIKEN cDNA A430102A20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304 Neighboring gene STARR-seq mESC enhancer starr_31376 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 3 Neighboring gene casein kinase 1, delta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression. Gurkaslar HK, et al. Cell Rep, 2020 May 12. PMID 32402286
    2. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Osipovich AB, et al. Genome Res, 2005 Mar. PMID 15741512, Free PMC Article
    3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 57
    NP_001404939.1
    NP_082021.1
    XP_006534297.1
    XP_017170256.1
    XP_030102182.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418010.1 → NP_001404939.1  coiled-coil domain-containing protein 57 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL662901, AL663090

    2. NM_027745.2 → NP_082021.1  coiled-coil domain-containing protein 57 isoform 1

      See identical proteins and their annotated locations for NP_082021.1

      Status: VALIDATED

      Source sequence(s)
      AL662901, AL663090
      Consensus CDS
      CCDS25760.1
      UniProtKB/Swiss-Prot
      Q6PHN1
      Related
      ENSMUSP00000050996.5, ENSMUST00000056781.5
      Conserved Domains (3) summary
      PHA03307
      Location:790 → 1008
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:3 → 320
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:7 → 698
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. NR_184673.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL662901, AL663090

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120717355..120823703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246322.1 → XP_030102182.1  coiled-coil domain-containing protein 57 isoform X4

      Conserved Domains (2) summary
      PHA03307
      Location:421 → 639
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02169
      Location:15 → 326
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. XM_017314767.3 → XP_017170256.1  coiled-coil domain-containing protein 57 isoform X1

      UniProtKB/Swiss-Prot
      Q6PHN1
      Conserved Domains (3) summary
      PHA03307
      Location:790 → 1008
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:3 → 320
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:7 → 698
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006534234.3 → XP_006534297.1  coiled-coil domain-containing protein 57 isoform X3

      Conserved Domains (2) summary
      PHA03307
      Location:623 → 841
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:14 → 386
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_004937031.1 RNA Sequence

    2. XR_004937029.1 RNA Sequence

    3. XR_001780051.3 RNA Sequence

    4. XR_003949508.2 RNA Sequence

    5. XR_001780052.3 RNA Sequence

    6. XR_004937034.1 RNA Sequence

    7. XR_004937033.1 RNA Sequence

    8. XR_004937032.1 RNA Sequence

    9. XR_001780053.3 RNA Sequence

    10. XR_003949507.2 RNA Sequence

    11. XR_004937030.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PHN1.1 GenPept UniProtKB/Swiss-Prot:Q6PHN1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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