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    Adprs ADP-ribosylserine hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 100206, updated on 9-May-2024

    Summary

    Official Symbol
    Adprsprovided by MGI
    Official Full Name
    ADP-ribosylserine hydrolaseprovided by MGI
    Primary source
    MGI:MGI:2140364
    See related
    Ensembl:ENSMUSG00000042558 AllianceGenome:MGI:2140364
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arh3; Adprhl2
    Summary
    Enables ADP-ribosylserine hydrolase activity and poly(ADP-ribose) glycohydrolase activity. Involved in peptidyl-serine ADP-deribosylation. Acts upstream of or within cellular response to superoxide. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human ADPRS (ADP-ribosylserine hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 51.4), adrenal adult (RPKM 31.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Adprs in Genome Data Viewer
    Location:
    4 D2.2; 4 60.36 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126210144..126215496, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126316351..126321703, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 3 Neighboring gene predicted gene, 54258 Neighboring gene collagen, type VIII, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125998967-125999150 Neighboring gene tektin 2 Neighboring gene STARR-seq mESC enhancer starr_11400 Neighboring gene argonaute RISC catalytic subunit 3 Neighboring gene STARR-seq mESC enhancer starr_11401 Neighboring gene STARR-positive B cell enhancer ABC_E7988

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP-ribosylserine hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ADP-ribosylserine hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables O-acetyl-ADP-ribose deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, hydrolyzing O-glycosyl compounds ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(ADP-ribose) glycohydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables poly(ADP-ribose) glycohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylhydrolase ARH3
    Names
    ADP-ribose glycohydrolase ARH3
    ADP-ribosylhydrolase 2
    ADP-ribosylhydrolase 3
    ADP-ribosylhydrolase like 2
    O-acetyl-ADP-ribose deacetylase ARH3
    [Protein ADP-ribosylarginine] hydrolase-like protein 2
    [Protein ADP-ribosylserine] hydrolase
    ecto ADP-ribosylhydrolase
    poly(ADP-ribose) glycohydrolase ARH3
    NP_598644.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133883.2NP_598644.1  ADP-ribosylhydrolase ARH3

      See identical proteins and their annotated locations for NP_598644.1

      Status: PROVISIONAL

      Source sequence(s)
      AL606976
      Consensus CDS
      CCDS18650.1
      UniProtKB/Swiss-Prot
      A3KFY3, Q80UW9, Q8CG72, Q8R575, Q921U6
      Related
      ENSMUSP00000099677.5, ENSMUST00000102617.5
      Conserved Domains (1) summary
      cl00614
      Location:28345
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      126210144..126215496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)