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    Prl8a8 prolactin family 8, subfamily a, member 81 [ Mus musculus (house mouse) ]

    Gene ID: 74188, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Prl8a8provided by MGI
    Official Full Name
    prolactin family 8, subfamily a, member 81provided by MGI
    Primary source
    MGI:MGI:1921438
    See related
    Ensembl:ENSMUSG00000021346 AllianceGenome:MGI:1921438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghd14; PLP-C3; Prlpc3; PLP-Cgamma; 1600032B14Rik
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including positive regulation of lactation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in extraembryonic component and placenta. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 35.6) See more
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    Genomic context

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    See Prl8a8 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.49 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27690951..27697200, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27506968..27513217, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 2, subfamily b, member 1 Neighboring gene predicted gene, 40836 Neighboring gene prolactin family 8, subfamily a, member 6 Neighboring gene prolactin family8, subfamily a, member 9 Neighboring gene prolactin family 8, subfamily a, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Plac1 (placenta-specific 1) is essential for normal placental and embryonic development. Jackman SM, et al. Mol Reprod Dev, 2012 Aug. PMID 22729990, Free PMC Article
    2. Assisted reproductive technologies induce temporally specific placental defects and the preeclampsia risk marker sFLT1 in mouse. Vrooman LA, et al. Development, 2020 May 29. PMID 32471820, Free PMC Article
    3. Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction. Inagaki M, et al. iScience, 2020 May 22. PMID 32408168, Free PMC Article
    4. Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice. Langford MB, et al. Sci Rep, 2018 Mar 2. PMID 29500366, Free PMC Article
    5. NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Park CB, et al. Biol Reprod, 2012 Jun. PMID 22378764, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolactin-8A8
    Names
    PLP-C gamma2
    PRL-like protein C3
    growth hormone d14
    placental prolactin-like protein C3
    prolactin-like protein C-gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311125.1 → NP_001298054.1  prolactin-8A8 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001298054.1

      Status: VALIDATED

      Source sequence(s)
      AK005568, BY035367
      Consensus CDS
      CCDS79173.1
      UniProtKB/Swiss-Prot
      Q8VHE8, Q9DAS4
      UniProtKB/TrEMBL
      A0A0M6L0I6
      Related
      ENSMUSP00000105979.2, ENSMUST00000110350.9
      Conserved Domains (1) summary
      cd10288
      Location:31 → 241
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    2. NM_001360895.1 → NP_001347824.1  prolactin-8A8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL590522
      Conserved Domains (1) summary
      cd10288
      Location:69 → 279
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    3. NM_001360896.1 → NP_001347825.1  prolactin-8A8 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL590522
      Consensus CDS
      CCDS88431.1
      UniProtKB/TrEMBL
      Q8CFH0
      Related
      ENSMUSP00000153131.2, ENSMUST00000224072.2
      Conserved Domains (1) summary
      cd10288
      Location:68 → 278
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    4. NM_023741.3 → NP_076230.1  prolactin-8A8 isoform 2 precursor

      See identical proteins and their annotated locations for NP_076230.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AL590522
      Consensus CDS
      CCDS26399.1
      UniProtKB/Swiss-Prot
      Q9DAS4
      Related
      ENSMUSP00000018389.4, ENSMUST00000018389.5
      Conserved Domains (1) summary
      cd10288
      Location:30 → 240
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27690951..27697200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAS4.1 GenPept UniProtKB/Swiss-Prot:Q9DAS4

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