Tfb2m transcription factor B2, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tfb2mprovided by MGI
Official Full Name: transcription factor B2, mitochondrialprovided by MGI
Primary source: MGI:MGI:107937
See related: Ensembl:ENSMUSG00000026492 AllianceGenome:MGI:107937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hkp1; mTFB2M; mtTFB2
Summary: Predicted to enable mitochondrial transcription factor activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation from mitochondrial promoter. Predicted to act upstream of or within methylation and rRNA processing. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human TFB2M (transcription factor B2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 8.1), heart adult (RPKM 6.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H4; 1 83.56 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (179355617..179373870, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (179528052..179546305, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Tfb2m in pancreatic beta-cells results in progressive mitochondrial dysfunction and impaired insulin secretion in response to metabolic stimuli.
Title: Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells.
Metazoans have two TFBM genes, suggesting that a duplication of the gene has permitted a more flexible regulation of mtDNA.
Title: Characterization of the mouse genes for mitochondrial transcription factors B1 and B2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tfb2m (e-PCR), detects polymorphism
- UniSTS:496732

Hkp1 (e-PCR), detects polymorphism
- UniSTS:143348

Hkp1 (e-PCR), detects polymorphism
- UniSTS:143349

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mitochondrial transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables mitochondrial transcription factor activity	ISO Inferred from Sequence Orthology more info
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial transcription	ISO Inferred from Sequence Orthology more info
involved_in rRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA modification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at mitochondrial promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at mitochondrial promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dimethyladenosine transferase 2, mitochondrial

Names: S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; house-keeping protein 1; mitochondrial 12S rRNA dimethylase 2; mitochondrial transcription factor B2

NP_001317983.1

EC 2.1.1.-

NP_001317984.1

EC 2.1.1.-

NP_001407149.1

EC 2.1.1.-

NP_001407150.1

EC 2.1.1.-

NP_001407151.1

EC 2.1.1.-

NP_001407152.1

EC 2.1.1.-

NP_001407153.1

EC 2.1.1.-

NP_032275.2

EC 2.1.1.-

XP_006496729.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001331054.2 → NP_001317983.1 dimethyladenosine transferase 2, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

AC130279

Conserved Domains (1) summary

cl17173
Location:81 → 356

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001331055.2 → NP_001317984.1 dimethyladenosine transferase 2, mitochondrial isoform 3

Status: VALIDATED

Source sequence(s)

AC130279

UniProtKB/Swiss-Prot

Q3TL26

Conserved Domains (1) summary

cl17173
Location:48 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001420220.1 → NP_001407149.1 dimethyladenosine transferase 2, mitochondrial isoform 4

Status: VALIDATED

Source sequence(s)

AC130279
NM_001420221.1 → NP_001407150.1 dimethyladenosine transferase 2, mitochondrial isoform 5

Status: VALIDATED

Source sequence(s)

AC130279
NM_001420222.1 → NP_001407151.1 dimethyladenosine transferase 2, mitochondrial isoform 6

Status: VALIDATED

Source sequence(s)

AC130279
NM_001420223.1 → NP_001407152.1 dimethyladenosine transferase 2, mitochondrial isoform 3

Status: VALIDATED

Source sequence(s)

AC130279
NM_001420224.1 → NP_001407153.1 dimethyladenosine transferase 2, mitochondrial isoform 7

Status: VALIDATED

Source sequence(s)

AC130279
NM_008249.6 → NP_032275.2 dimethyladenosine transferase 2, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_032275.2

Status: VALIDATED

Source sequence(s)

AC130279

Consensus CDS

CCDS15561.1

UniProtKB/Swiss-Prot

Q3TL26, Q61669, Q8BTJ2

UniProtKB/TrEMBL

B2RSE6

Related

ENSMUSP00000027769.6, ENSMUST00000027769.6

Conserved Domains (1) summary

cl17173
Location:81 → 377

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

179355617..179373870 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496666.3 → XP_006496729.1 dimethyladenosine transferase 2, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006496729.1

Conserved Domains (1) summary

cl17173
Location:48 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...