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    rept reptin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40092, updated on 10-May-2024

    Summary

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    Official Symbol
    reptprovided by FlyBase
    Official Full Name
    reptinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040075
    Locus tag
    Dmel_CG9750
    See related
    AllianceGenome:FB:FBgn0040075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0142479.1; CG9750; Dmel\CG9750; drep; dRep; dReptin; dRUVBL2; l(3)06945; psg10; Q9V3K3_DROME; rep; REP; Rept; REPT; Reptin; Tip48; Tip48/Reptin
    Summary
    Enables transcription corepressor activity. Involved in several processes, including chromatin organization; instar larval or pupal morphogenesis; and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Located in nucleus. Part of Ino80 complex and NuA4 histone acetyltransferase complex. Is expressed in several structures, including embryonic central brain; embryonic/larval digestive system; extended germ band embryo; gastrula embryo; and stage 5 embryo. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See rept in Genome Data Viewer
    Location:
    76A3-76A3; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19255340..19257111)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19248440..19250211)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46216 Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene antisense RNA:CR45210 Neighboring gene nessy Neighboring gene Blocked early in transport 1 Neighboring gene Max

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes. Huen J, et al. Biochem Cell Biol, 2010 Feb. PMID 20130677
    2. Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Bellosta P, et al. Proc Natl Acad Sci U S A, 2005 Aug 16. PMID 16087886, Free PMC Article
    3. A Simple Cross-Linking/Mass Spectrometry Workflow for Studying System-wide Protein Interactions. Götze M, et al. Anal Chem, 2019 Aug 6. PMID 31283178
    4. Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6. Lennon J, et al. Front Genet, 2022. PMID 35873488, Free PMC Article
    5. Spaghetti, a homolog of human RPAP3 (RNA polymerase II-associated protein 3), determines the fate of germline stem cells in Drosophila ovary. Chen D, et al. Cell Biol Int, 2018 Jul. PMID 29110400

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WAC promotes the interaction between TTT and Pontin/Reptin in an energy-dependent manner, thereby promoting mTORC1 activity by facilitating mTORC1 dimerization and mTORC1-Rag interaction
      Title: WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.
    2. The enzymatic functions of Rept and Pont are indispensable for maintaining Hox gene expression states, highlighting the importance of these two antagonistic factors in transcriptional output.
      Title: Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control.
    3. Rept and pontin have conserved their ability to bind to Myc during evolution
      Title: Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.
    4. Drosophila Reptin participates in epigenetic processes leading to a repressive chromatin state.
      Title: Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in autophagic cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in box C/D snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ecdysone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of R2TP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of R2TP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reptin
    Names
    CG9750-PA
    CG9750-PB
    CG9750-PC
    dReptin
    rept-PA
    rept-PB
    rept-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19255340..19257111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079432.3 → NP_524156.1  reptin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524156.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3K3
      UniProtKB/TrEMBL
      M9PFN1
      Related
      FBpp0074756
      Conserved Domains (3) summary
      cd00009
      Location:267 → 358
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      pfam06068
      Location:17 → 408
      TIP49; TIP49 C-terminus
      cl21455
      Location:69 → 113
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001300184.1 → NP_001287113.1  reptin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287113.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3K3
      UniProtKB/TrEMBL
      M9PFN1
      Conserved Domains (3) summary
      cd00009
      Location:267 → 358
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      pfam06068
      Location:17 → 408
      TIP49; TIP49 C-terminus
      cl21455
      Location:69 → 113
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001275111.1 → NP_001262040.1  reptin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262040.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3K3
      UniProtKB/TrEMBL
      M9PFN1
      Conserved Domains (3) summary
      cd00009
      Location:267 → 358
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      pfam06068
      Location:17 → 408
      TIP49; TIP49 C-terminus
      cl21455
      Location:69 → 113
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFN1 M9PFN1
    Q9V3K3.1 Q9V3K3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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