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    CG3597 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33420, updated on 10-May-2024

    Summary

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    Official Symbol
    CG3597provided by FlyBase
    Primary source
    FLYBASE:FBgn0031417
    Locus tag
    Dmel_CG3597
    See related
    AllianceGenome:FB:FBgn0031417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BVRA; Dmel\CG3597
    Summary
    Predicted to enable oxidoreductase activity. Is expressed in adult head; head mesoderm; and plasmatocyte primordium. Orthologous to human DHDH (dihydrodiol dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG3597 in Genome Data Viewer
    Location:
    22E1-22E1; 2-6 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2370152..2371524, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2370152..2371524, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rab5 Neighboring gene AXIN1 up-regulated 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44982 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain. Mahr A, et al. Gene Expr Patterns, 2006 Mar. PMID 16378756
    2. Chronic low-dose γ-irradiation of Drosophila melanogaster larvae induces gene expression changes and enhances locomotive behavior. Kim CS, et al. J Radiat Res, 2015 May. PMID 25792464, Free PMC Article
    3. The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila. King-Jones K, et al. Cell Metab, 2006 Jul. PMID 16814731
    4. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-xylose 1-dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-xylose catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3597-PA
    CG3597-PB
    NP_001259930.1
    NP_608674.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2370152..2371524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134830.2 → NP_608674.1  uncharacterized protein Dmel_CG3597, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX02, Q9VQB3
      Related
      FBpp0077469
      Conserved Domains (3) summary
      COG0673
      Location:7 → 330
      MviM; Predicted dehydrogenase [General function prediction only]
      pfam01408
      Location:7 → 128
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      cl21649
      Location:140 → 226
      GFO_IDH_MocA_C; Oxidoreductase family, C-terminal alpha/beta domain

    2. NM_001273001.1 → NP_001259930.1  uncharacterized protein Dmel_CG3597, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE54, Q8SX02
      Conserved Domains (3) summary
      COG0673
      Location:7 → 332
      MviM; Predicted dehydrogenase [General function prediction only]
      pfam01408
      Location:7 → 127
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      cl21649
      Location:142 → 228
      GFO_IDH_MocA_C; Oxidoreductase family, C-terminal alpha/beta domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PE54 M9PE54
    Q8SX02 Q8SX02
    Q9VQB3 Q9VQB3

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