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    Pbx4 pre B cell leukemia homeobox 4 [ Mus musculus (house mouse) ]

    Gene ID: 80720, updated on 27-May-2024

    Summary

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    Official Symbol
    Pbx4provided by MGI
    Official Full Name
    pre B cell leukemia homeobox 4provided by MGI
    Primary source
    MGI:MGI:1931321
    See related
    Ensembl:ENSMUSG00000031860 AllianceGenome:MGI:1931321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410015M21Rik
    Summary
    Enables sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Located in XY body. Is expressed in several structures, including early conceptus; eye; gonad; heart; and urinary system. Orthologous to human PBX4 (PBX homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 58.8), whole brain E14.5 (RPKM 4.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pbx4 in Genome Data Viewer
    Location:
    8 B3.3; 8 33.92 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70285127..70324942)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69832476..69872292)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Gem-interacting protein Neighboring gene predicted gene, 33695 Neighboring gene lysophosphatidic acid receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2867 Neighboring gene STARR-seq mESC enhancer starr_21749 Neighboring gene predicted gene, 33746 Neighboring gene cartilage intermediate layer protein 2 Neighboring gene YjeF N-terminal domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish. Vlachakis N, et al. Development, 2001 Apr. PMID 11262231
    2. In vivo analysis of developmentally and evolutionarily dynamic protein-DNA interactions regulating transcription of the Pgk2 gene during mammalian spermatogenesis. Yoshioka H, et al. Mol Cell Biol, 2007 Nov. PMID 17875925, Free PMC Article
    3. Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis. Wagner K, et al. Mech Dev, 2001 May. PMID 11335119
    4. Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins. Rivera-Reyes R, et al. PLoS One, 2018. PMID 30071041, Free PMC Article
    5. Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Ferretti E, et al. Mol Cell Biol, 2006 Aug. PMID 16847320, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcription factor PBX4 regulates limb development and haematopoiesis in mice.
      Title: Transcription factor PBX4 regulates limb development and haematopoiesis in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in XY body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pre-B-cell leukemia transcription factor 4
    Names
    homeobox protein PBX4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024954.2 → NP_001020125.1  pre-B-cell leukemia transcription factor 4 isoform 1

      See identical proteins and their annotated locations for NP_001020125.1

      Status: VALIDATED

      Source sequence(s)
      AC158564
      Consensus CDS
      CCDS22352.1
      UniProtKB/Swiss-Prot
      Q8CFL2, Q99NE8, Q99NE9
      Related
      ENSMUSP00000080219.6, ENSMUST00000081503.13
      Conserved Domains (2) summary
      cd00086
      Location:216 → 276
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:25 → 214
      PBC; PBC domain

    2. NM_001357308.1 → NP_001344237.1  pre-B-cell leukemia transcription factor 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158564, BC032875
      Conserved Domains (2) summary
      cd00086
      Location:38 → 98
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:1 → 36
      PBC; PBC domain

    RNA

    1. NR_151668.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158564, AK038786
      Related
      ENSMUST00000134777.10

    2. NR_151669.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158564, AK010506, BC032875
      Related
      ENSMUST00000132899.8

    3. NR_151670.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158564, BC032875, BY097743

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70285127..70324942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509800.3 → XP_006509863.1  pre-B-cell leukemia transcription factor 4 isoform X1

      Conserved Domains (2) summary
      pfam03792
      Location:25 → 214
      PBC; PBC domain
      pfam05920
      Location:216 → 249
      Homeobox_KN; Homeobox KN domain

    2. XM_030243861.2 → XP_030099721.1  pre-B-cell leukemia transcription factor 4 isoform X2

      Conserved Domains (2) summary
      cd00086
      Location:38 → 98
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:1 → 36
      PBC; PBC domain

    3. XM_030243862.2 → XP_030099722.1  pre-B-cell leukemia transcription factor 4 isoform X2

      Conserved Domains (2) summary
      cd00086
      Location:38 → 98
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:1 → 36
      PBC; PBC domain

    4. XM_030243864.1 → XP_030099724.1  pre-B-cell leukemia transcription factor 4 isoform X2

      Conserved Domains (2) summary
      cd00086
      Location:38 → 98
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:1 → 36
      PBC; PBC domain

    RNA

    1. XR_001778490.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99NE9.2 GenPept UniProtKB/Swiss-Prot:Q99NE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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