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    Tgif2 TGFB-induced factor homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 228839, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tgif2provided by MGI
    Official Full Name
    TGFB-induced factor homeobox 2provided by MGI
    Primary source
    MGI:MGI:1915299
    See related
    Ensembl:ENSMUSG00000062175 AllianceGenome:MGI:1915299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921501K24; 5730599O09Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nodal signaling pathway; positive regulation of neuron differentiation; and regulation of gastrulation. Predicted to be located in centrosome and nucleoplasm. Is expressed in several structures, including alimentary system; brain; forelimb phalanx; genitourinary system; and sensory organ. Orthologous to several human genes including TGIF2-RAB5IF (TGIF2-RAB5IF readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.1), limb E14.5 (RPKM 10.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tgif2 in Genome Data Viewer
    Location:
    2 H1; 2 77.86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156681737..156697490)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156839817..156855570)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06181 Neighboring gene myosin, light polypeptide 9, regulatory Neighboring gene STARR-seq mESC enhancer starr_06182 Neighboring gene ribosomal protein L9 pseudogene Neighboring gene VISTA enhancer mm1377 Neighboring gene predicted gene 14230 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156665530-156665639 Neighboring gene RIKEN cDNA 5430405H02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1606 Neighboring gene RAB5 interacting factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156712828-156713029 Neighboring gene Src-like-adaptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice. Lei J, et al. Brain Behav, 2022 Jun. PMID 35592894, Free PMC Article
    2. TGFβ-induced factor homeobox 2 blocks osteoblastic differentiation through targeting pSmad3/HDAC4/H4ac/Runx2 axis. Yu X, et al. J Cell Physiol, 2019 Nov. PMID 31066043
    3. Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer. Tao W, et al. Thorac Cancer, 2021 Dec. PMID 34741437, Free PMC Article
    4. The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm. Spagnoli FM, et al. Development, 2008 Feb. PMID 18094028
    5. The Tgif2 gene contains a retained intron within the coding sequence. Melhuish TA, et al. BMC Mol Biol, 2006 Jan 25. PMID 16436215, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice.
      Title: Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice.
    2. Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.
      Title: Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.
    3. Gm14230 safeguards cellular juvenescence through recruiting the histone methyltransferase Ezh2 to Tgif2, thereby repressing the functional role of Tgif2 in cellular senescence.
      Title: The juvenility-associated long noncoding RNA Gm14230 maintains cellular juvenescence.
    4. Tgif2 plays an important role in the regulation of osteoblastic differentiation in vitro
      Title: TGFβ-induced factor homeobox 2 blocks osteoblastic differentiation through targeting pSmad3/HDAC4/H4ac/Runx2 axis.
    5. Tgifs play an important role in regulating basic energy metabolism in normal cells, and that this function of Tgifs is amplified in some cancers.
      Title: TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.
    6. Studies indicate the reprogramming activity of TG-interacting factor 2 (TGIF2) and suggest a stepwise reprogramming paradigm.
      Title: Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
    7. Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect.
      Title: Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.
    8. loss of Tgif1 causes axial patterning defects that are enhanced by mutations in Tgif2
      Title: Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.
    9. Data show that loss-of-function mutations in both Tgif1 and Tgif2 result in a failure of gastrulation.
      Title: Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.
    10. TGIF2 is the molecular link between dorsoventral patterning of the endoderm and pancreatic specification.
      Title: The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of amacrine cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nodal signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of amacrine cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein TGIF2
    Names
    5'-TG-3'-interacting factor 2
    TALE family homeobox
    TGF-beta-induced transcription factor 2
    TGFB-induced factor 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291124.1 → NP_001278053.1  homeobox protein TGIF2 isoform b

      See identical proteins and their annotated locations for NP_001278053.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK029490, AL935150, BQ030806, CF731285
      Consensus CDS
      CCDS71173.1
      UniProtKB/TrEMBL
      Q3TZS1
      Related
      ENSMUSP00000073074.4, ENSMUST00000073352.10
      Conserved Domains (1) summary
      pfam05920
      Location:36 → 75
      Homeobox_KN; Homeobox KN domain

    2. NM_173396.3 → NP_775572.1  homeobox protein TGIF2 isoform a

      See identical proteins and their annotated locations for NP_775572.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK029490, AL935150, BQ030806
      Consensus CDS
      CCDS16969.1
      UniProtKB/Swiss-Prot
      Q8C0Y1
      UniProtKB/TrEMBL
      A2AVY9
      Related
      ENSMUSP00000096745.5, ENSMUST00000081335.13
      Conserved Domains (1) summary
      pfam05920
      Location:36 → 75
      Homeobox_KN; Homeobox KN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      156681737..156697490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499353.3 → XP_006499416.1  homeobox protein TGIF2 isoform X1

      See identical proteins and their annotated locations for XP_006499416.1

      UniProtKB/Swiss-Prot
      Q8C0Y1
      UniProtKB/TrEMBL
      A2AVY9
      Conserved Domains (1) summary
      pfam05920
      Location:36 → 75
      Homeobox_KN; Homeobox KN domain

    2. XM_006499354.5 → XP_006499417.1  homeobox protein TGIF2 isoform X1

      See identical proteins and their annotated locations for XP_006499417.1

      UniProtKB/Swiss-Prot
      Q8C0Y1
      UniProtKB/TrEMBL
      A2AVY9
      Conserved Domains (1) summary
      pfam05920
      Location:36 → 75
      Homeobox_KN; Homeobox KN domain

    3. XM_036161592.1 → XP_036017485.1  homeobox protein TGIF2 isoform X2

      UniProtKB/TrEMBL
      Q3TZS1
      Conserved Domains (1) summary
      pfam05920
      Location:36 → 75
      Homeobox_KN; Homeobox KN domain

    4. XM_006499351.5 → XP_006499414.1  homeobox protein TGIF2 isoform X1

      See identical proteins and their annotated locations for XP_006499414.1

      UniProtKB/Swiss-Prot
      Q8C0Y1
      UniProtKB/TrEMBL
      A2AVY9
      Conserved Domains (1) summary
      pfam05920
      Location:36 → 75
      Homeobox_KN; Homeobox KN domain

    5. XM_030250654.2 → XP_030106514.1  homeobox protein TGIF2 isoform X2

      UniProtKB/TrEMBL
      Q3TZS1
      Conserved Domains (1) summary
      pfam05920
      Location:36 → 75
      Homeobox_KN; Homeobox KN domain

    6. XM_036161591.1 → XP_036017484.1  homeobox protein TGIF2 isoform X2

      UniProtKB/TrEMBL
      Q3TZS1
      Conserved Domains (1) summary
      pfam05920
      Location:36 → 75
      Homeobox_KN; Homeobox KN domain

    7. XM_006499352.5 → XP_006499415.1  homeobox protein TGIF2 isoform X1

      See identical proteins and their annotated locations for XP_006499415.1

      UniProtKB/Swiss-Prot
      Q8C0Y1
      UniProtKB/TrEMBL
      A2AVY9
      Conserved Domains (1) summary
      pfam05920
      Location:36 → 75
      Homeobox_KN; Homeobox KN domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0Y1.1 GenPept UniProtKB/Swiss-Prot:Q8C0Y1

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