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    Mov10 Mov10 RNA helicase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310756, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Mov10provided by RGD
    Official Full Name
    Mov10 RNA helicaseprovided by RGD
    Primary source
    RGD:1598327
    See related
    Ensembl:ENSRNOG00000012946 AllianceGenome:RGD:1598327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Capza1
    Summary
    Predicted to enable 5'-3' RNA helicase activity and RNA binding activity. Predicted to be involved in several processes, including negative regulation of transposition, RNA-mediated; posttranscriptional regulation of gene expression; and regulation of neuron projection arborization. Predicted to be located in P-body and nucleus. Predicted to be active in P granule and cytosol. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human MOV10 (Mov10 RISC complex RNA helicase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 52.9), Kidney (RPKM 45.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mov10 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (194982014..195003513, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (192292041..192315142, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (207277088..207301245, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 3 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1J Neighboring gene ras homolog family member C Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene suppression of tumorigenicity 7-like Neighboring gene Wnt family member 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP. Kute PM, et al. Mol Brain, 2019 Jul 10. PMID 31291981, Free PMC Article
    2. Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain. Skariah G, et al. BMC Biol, 2017 Jun 29. PMID 28662698, Free PMC Article
    3. MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells. Goodier JL, et al. PLoS Genet, 2012. PMID 23093941, Free PMC Article
    4. Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population. Hong GL, et al. Genet Mol Res, 2013 Dec 4. PMID 24338417
    5. Identification of novel argonaute-associated proteins. Meister G, et al. Curr Biol, 2005 Dec 6. PMID 16289642

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FMRP and MOV10 have an important regulatory role in NMDAR mediated translation at the synapse.
      Title: NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-3' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection arborization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrotransposon silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrotransposon silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    helicase MOV-10
    Names
    Moloney leukemia virus 10
    Mov10 RISC complex RNA helicase
    Mov10, Moloney leukemia virus 10
    capping protein (actin filament) muscle Z-line, alpha 1
    putative helicase MOV-10
    NP_001101181.1
    NP_001380739.1
    XP_017446407.1
    XP_063137981.1
    XP_063137982.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107711.2 → NP_001101181.1  helicase MOV-10

      See identical proteins and their annotated locations for NP_001101181.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K3P8, D3ZUC2
      Conserved Domains (2) summary
      cd18808
      Location:735 → 940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499 → 734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    2. NM_001393810.1 → NP_001380739.1  helicase MOV-10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K3P8, D3ZUC2
      Related
      ENSRNOP00000018061.5, ENSRNOT00000018061.7
      Conserved Domains (2) summary
      cd18808
      Location:735 → 940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499 → 734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      194982014..195003513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590918.3 → XP_017446407.1  helicase MOV-10 isoform X1

      UniProtKB/TrEMBL
      A6K3P8, D3ZUC2
      Conserved Domains (2) summary
      cd18808
      Location:735 → 940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499 → 734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    2. XM_063281911.1 → XP_063137981.1  helicase MOV-10 isoform X2

      UniProtKB/TrEMBL
      D3ZUC2

    3. XM_063281912.1 → XP_063137982.1  helicase MOV-10 isoform X3

    RNA

    1. XR_010063612.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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