Npl N-acetylneuraminate pyruvate lyase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nplprovided by MGI
Official Full Name: N-acetylneuraminate pyruvate lyaseprovided by MGI
Primary source: MGI:MGI:1921341
See related: Ensembl:ENSMUSG00000042684 AllianceGenome:MGI:1921341
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610033B02Rik
Summary: Enables N-acetylneuraminate lyase activity. Predicted to be involved in N-acetylneuraminate catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in cytoplasm. Is expressed in 2-cell stage embryo; eye; and nervous system. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 95.4), kidney adult (RPKM 16.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 65.38 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (153378762..153425460, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (153503016..153549714, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function.
Title: N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function.
This study demonstrates PR-mediated dynamic expression of Npl in the periimplantation uterus and dispensable role of Npl in uterine function and embryo development.
Title: Progesterone receptor-mediated regulation of N-acetylneuraminate pyruvate lyase (NPL) in mouse uterine luminal epithelium and nonessential role of NPL in uterine function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Npl (e-PCR), detects polymorphism
- UniSTS:546899

AV000645 (e-PCR)
- UniSTS:178789

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetylneuraminate lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylneuraminate lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylneuraminate lyase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylneuraminate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylneuraminate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in N-acetylneuraminate catabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetylneuraminate lyase

Names: N-acetylneuraminic acid aldolase; NALase; sialate lyase; sialate-pyruvate lyase; sialic acid aldolase; sialic acid lyase

NP_083025.1

EC 4.1.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028749.1 → NP_083025.1 N-acetylneuraminate lyase

See identical proteins and their annotated locations for NP_083025.1

Status: PROVISIONAL

Source sequence(s)

AK002734

Consensus CDS

CCDS15374.1

UniProtKB/Swiss-Prot

Q9DCJ9

Related

ENSMUSP00000037454.8, ENSMUST00000041874.9

Conserved Domains (1) summary

cl21457
Location:8 → 306

TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...