esrrga estrogen-related receptor gamma a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: esrrgaprovided by ZNC
Official Full Name: estrogen-related receptor gamma aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030821-2
See related: Ensembl:ENSDARG00000004861 AllianceGenome:ZFIN:ZDB-GENE-030821-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: errg; esrrg; errgamma
Summary: Enables DNA-binding transcription factor activity. Acts upstream of or within otic vesicle development and transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in basal plate midbrain region; nervous system; pronephric duct; and tail bud. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to several human genes including ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (29794802..30052136, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (29777839..30035161, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular steroid hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within otic vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: estrogen-related receptor gamma a; estrogen-related receptor gamma

Names: NR3B3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212954.1 → NP_998119.1 estrogen-related receptor gamma a

See identical proteins and their annotated locations for NP_998119.1

Status: PROVISIONAL

Source sequence(s)

AY556397

UniProtKB/TrEMBL

A0A0G2KVP5, A0A8N1Z284, Q6Q6F4

Related

ENSDARP00000136509.2, ENSDART00000166976.2

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

29794802..30052136 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467134.1 → XP_021322809.1 estrogen-related receptor gamma isoform X7

UniProtKB/TrEMBL

A0A8M9PNM9

Conserved Domains (2) summary

cd06946
Location:225 → 444

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 199

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_021467132.1 → XP_021322807.1 estrogen-related receptor gamma isoform X5

UniProtKB/TrEMBL

A0A8M9PKM0

Conserved Domains (2) summary

cd06946
Location:272 → 491

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:146 → 246

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_021467133.1 → XP_021322808.1 estrogen-related receptor gamma isoform X6

UniProtKB/TrEMBL

A0A8M9P8U5

Conserved Domains (2) summary

cd06946
Location:248 → 467

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:122 → 222

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_021467130.1 → XP_021322805.1 estrogen-related receptor gamma isoform X3

UniProtKB/TrEMBL

A0A8M9PNM6

Conserved Domains (2) summary

cd06946
Location:284 → 503

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:165 → 265

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_009293126.3 → XP_009291401.1 estrogen-related receptor gamma isoform X4

UniProtKB/TrEMBL

A0A8M3B2H9, F6PD98

Related

ENSDARP00000005364.5, ENSDART00000009104.6

Conserved Domains (2) summary

cd06946
Location:280 → 499

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:165 → 261

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_021467129.1 → XP_021322804.1 estrogen-related receptor gamma isoform X1

UniProtKB/TrEMBL

A0A8M9PE48

Conserved Domains (2) summary

cd06946
Location:291 → 510

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:165 → 265

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_021467131.1 → XP_021322806.1 estrogen-related receptor gamma isoform X5

UniProtKB/TrEMBL

A0A8M9PKM0

Conserved Domains (2) summary

cd06946
Location:272 → 491

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:146 → 246

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_005158771.4 → XP_005158828.1 estrogen-related receptor gamma isoform X2

UniProtKB/TrEMBL

A0A8M2B590

Conserved Domains (2) summary

cd06946
Location:287 → 506

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:165 → 261

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_021467135.1 → XP_021322810.1 estrogen-related receptor gamma isoform X7

UniProtKB/TrEMBL

A0A8M9PNM9

Conserved Domains (2) summary

cd06946
Location:225 → 444

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 199

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers