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    osbpl7 oxysterol binding protein-like 7 [ Danio rerio (zebrafish) ]

    Gene ID: 449656, updated on 25-Apr-2024

    Summary

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    Official Symbol
    osbpl7provided by ZNC
    Official Full Name
    oxysterol binding protein-like 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-212
    See related
    Ensembl:ENSDARG00000012981 AllianceGenome:ZFIN:ZDB-GENE-041010-212
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    osbpl6; zgc:92595; wu:fu06e07
    Summary
    Predicted to enable cholesterol binding activity and sterol transporter activity. Predicted to act upstream of or within lipid transport. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is expressed in EVL; epidermis; periderm; pharynx; and retina. Orthologous to human OSBPL7 (oxysterol binding protein like 7). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See osbpl7 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (28773581..28795075, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (28657652..28680173, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene TBK1 binding protein 1 Neighboring gene T-box transcription factor 21 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene proline rich 15 like b Neighboring gene pyridoxamine 5'-phosphate oxidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio. Mitra S, et al. FEBS J, 2010 Jan. PMID 19961539
    2. A vertebrate model for the study of lipid binding/transfer protein function: conservation of OSBP-related proteins between zebrafish and human. Zhou Y, et al. Biochem Biophys Res Commun, 2014 Apr 11. PMID 24326072
    3. Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes. Sundström G, et al. Gen Comp Endocrinol, 2008 Feb 1. PMID 17950734
    4. Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. Sundström G, et al. BMC Evol Biol, 2008 Sep 19. PMID 18803835, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 7
    Names
    oxysterol binding protein-like 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005927.1 → NP_001005927.1  oxysterol-binding protein-related protein 7

      See identical proteins and their annotated locations for NP_001005927.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083531
      UniProtKB/TrEMBL
      Q5XIY7
      Related
      ENSDARP00000013230.7, ENSDART00000020667.9
      Conserved Domains (3) summary
      cd13287
      Location:41 → 170
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:70 → 160
      PH; PH domain
      pfam01237
      Location:523 → 865
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      28773581..28795075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306611.3 → XP_009304886.1  oxysterol-binding protein-related protein 7 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B4J5
      Conserved Domains (3) summary
      cd13287
      Location:41 → 170
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:70 → 160
      PH; PH domain
      pfam01237
      Location:492 → 834
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_009306610.3 → XP_009304885.1  oxysterol-binding protein-related protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A8M3B7C6
      Conserved Domains (3) summary
      cd13287
      Location:41 → 170
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:70 → 160
      PH; PH domain
      pfam01237
      Location:514 → 856
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_009306607.3 → XP_009304882.1  oxysterol-binding protein-related protein 7 isoform X1

      See identical proteins and their annotated locations for XP_009304882.1

      UniProtKB/TrEMBL
      A0A8M3BE40
      Conserved Domains (3) summary
      cd13287
      Location:41 → 170
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:70 → 160
      PH; PH domain
      pfam01237
      Location:545 → 887
      Oxysterol_BP; Oxysterol-binding protein

    4. XM_009306608.3 → XP_009304883.1  oxysterol-binding protein-related protein 7 isoform X1

      See identical proteins and their annotated locations for XP_009304883.1

      UniProtKB/TrEMBL
      A0A8M3BE40
      Conserved Domains (3) summary
      cd13287
      Location:41 → 170
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:70 → 160
      PH; PH domain
      pfam01237
      Location:545 → 887
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_009306609.3 → XP_009304884.1  oxysterol-binding protein-related protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AY80
      Conserved Domains (3) summary
      cd13287
      Location:41 → 170
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:70 → 160
      PH; PH domain
      pfam01237
      Location:531 → 873
      Oxysterol_BP; Oxysterol-binding protein

    6. XM_021480054.1 → XP_021335729.1  oxysterol-binding protein-related protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QE65
      Conserved Domains (2) summary
      cd13287
      Location:41 → 170
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:537 → 879
      Oxysterol_BP; Oxysterol-binding protein

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394848.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      216074..237241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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