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    mypn myopalladin [ Danio rerio (zebrafish) ]

    Gene ID: 571695, updated on 27-Mar-2024

    Summary

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    Official Symbol
    mypnprovided by ZNC
    Official Full Name
    myopalladinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100721-5
    See related
    AllianceGenome:ZFIN:ZDB-GENE-100721-5
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc17a02
    Summary
    Is expressed in heart. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1KK and nemaline myopathy 11. Orthologous to human MYPN (myopalladin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See mypn in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (50257978..50321941, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (49944741..50008624, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 2 Neighboring gene G patch domain containing 11 Neighboring gene CDK2 associated cullin domain 1 Neighboring gene sirtuin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Thyroid Hormone Receptor α Mutations Cause Heart Defects in Zebrafish. Han CR, et al. Thyroid, 2021 Feb. PMID 32762296, Free PMC Article
    2. Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells. Hsieh FC, et al. Sci Rep, 2018 May 18. PMID 29777134, Free PMC Article
    3. Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish. Shih YH, et al. Circ Cardiovasc Genet, 2015 Apr. PMID 25583992, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    myopalladin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365297.1 → NP_001352226.1  myopalladin isoform 1

      Status: VALIDATED

      Source sequence(s)
      CU928131, CU929278
      UniProtKB/TrEMBL
      A0A8N7UTI8
      Conserved Domains (4) summary
      pfam07679
      Location:236 → 322
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1775 → 1849
      Ig; Immunoglobulin domain
      cl26464
      Location:998 → 1456
      Atrophin-1; Atrophin-1 family
      cl26557
      Location:375 → 545
      RNase_E_G; Ribonuclease E/G family

    2. NM_001365298.1 → NP_001352227.1  myopalladin isoform 2

      Status: VALIDATED

      Source sequence(s)
      CU928131, CU929278
      UniProtKB/TrEMBL
      A0A8M9QNY4
      Conserved Domains (4) summary
      pfam07679
      Location:236 → 322
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1748 → 1822
      Ig; Immunoglobulin domain
      cl26464
      Location:998 → 1456
      Atrophin-1; Atrophin-1 family
      cl26557
      Location:375 → 545
      RNase_E_G; Ribonuclease E/G family

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      50257978..50321941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480910.1 → XP_021336585.1  myopalladin isoform X2

      Conserved Domains (4) summary
      pfam07679
      Location:236 → 322
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1748 → 1822
      Ig; Immunoglobulin domain
      cl26464
      Location:998 → 1456
      Atrophin-1; Atrophin-1 family
      cl26557
      Location:375 → 545
      RNase_E_G; Ribonuclease E/G family

    2. XM_695308.9 → XP_700400.6  myopalladin isoform X1

      Conserved Domains (4) summary
      pfam07679
      Location:236 → 322
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1775 → 1849
      Ig; Immunoglobulin domain
      cl26464
      Location:998 → 1456
      Atrophin-1; Atrophin-1 family
      cl26557
      Location:375 → 545
      RNase_E_G; Ribonuclease E/G family
    Nucleotide Protein
    Heading Accession and Version

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