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    lyst lysosomal trafficking regulator [ Danio rerio (zebrafish) ]

    Gene ID: 100150726, updated on 27-Mar-2024

    Summary

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    Official Symbol
    lystprovided by ZNC
    Official Full Name
    lysosomal trafficking regulatorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070702-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-070702-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-30i2.1
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to act upstream of or within lysosome organization. Predicted to be active in cytosol and membrane. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome. Orthologous to human LYST (lysosomal trafficking regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See lyst in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (49866497..50062745, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (49553049..49749498, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 2 Neighboring gene G protein subunit gamma 4 Neighboring gene nidogen 1a Neighboring gene G protein-coupled receptor 137Ba

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A post-developmental genetic screen for zebrafish models of inherited liver disease. Kim SH, et al. PLoS One, 2015. PMID 25950913, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal-trafficking regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      49866497..50062745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009307601.3 → XP_009305876.1  lysosomal-trafficking regulator isoform X2

      UniProtKB/TrEMBL
      A0A8M3AZH9
      Conserved Domains (5) summary
      smart01026
      Location:3163 → 3453
      Beach; Beige/BEACH domain
      COG2319
      Location:3567 → 3830
      WD40; WD40 repeat [General function prediction only]
      cd01201
      Location:3043 → 3148
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:3559 → 3596
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:3560 → 3809
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_017358861.2 → XP_017214350.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z2E9

    3. XM_017358862.2 → XP_017214351.1  lysosomal-trafficking regulator isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z3Z4

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394890.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      61731..245158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472744.1 → XP_021328419.1  lysosomal-trafficking regulator isoform X2

      UniProtKB/TrEMBL
      A0A8M9PU84
      Conserved Domains (4) summary
      smart01026
      Location:3163 → 3453
      Beach; Beige/BEACH domain
      cd01201
      Location:3043 → 3148
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:3559 → 3596
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:3560 → 3809
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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