pole3 polymerase (DNA directed), epsilon 3 (p17 subunit) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pole3provided by ZNC
Official Full Name: polymerase (DNA directed), epsilon 3 (p17 subunit)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1773
See related: Ensembl:ENSDARG00000008551 AllianceGenome:ZFIN:ZDB-GENE-040426-1773
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73351
Summary: Predicted to enable chromatin DNA binding activity. Predicted to be involved in cellular response to DNA damage stimulus; chromatin organization; and leading strand elongation. Predicted to be part of CHRAC and epsilon DNA polymerase complex. Is expressed in alar plate midbrain region; immature eye; nervous system; pectoral fin; and pharyngeal arch 3-7 skeleton. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (32888119..32890711, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (32287966..32290558, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of CHRAC	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA polymerase epsilon subunit 3

NP_957095.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200801.1 → NP_957095.1 DNA polymerase epsilon subunit 3

See identical proteins and their annotated locations for NP_957095.1

Status: PROVISIONAL

Source sequence(s)

BC059666

UniProtKB/TrEMBL

A0A8M1PHY0, Q6PBL4

Related

ENSDARP00000002886.5, ENSDART00000007512.7

Conserved Domains (1) summary

cl23735
Location:1 → 120

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...