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    Atp11c ATPase, class VI, type 11C [ Mus musculus (house mouse) ]

    Gene ID: 320940, updated on 12-May-2024

    Summary

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    Official Symbol
    Atp11cprovided by MGI
    Official Full Name
    ATPase, class VI, type 11Cprovided by MGI
    Primary source
    MGI:MGI:1859661
    See related
    Ensembl:ENSMUSG00000062949 AllianceGenome:MGI:1859661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ig; A330005H02Rik
    Summary
    Predicted to enable phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Involved in phospholipid translocation; positive regulation of B cell differentiation; and pre-B cell differentiation. Predicted to be integral component of plasma membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; recycling endosome; and trans-Golgi network. Is expressed in choroid invagination; diencephalon roof plate; and metencephalon part of 4th ventricle choroid plexus. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia. Orthologous to human ATP11C (ATPase phospholipid transporting 11C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E14 (RPKM 7.2), whole brain E14.5 (RPKM 6.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp11c in Genome Data Viewer
    Location:
    X A6; X 33.5 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (59268643..59450041, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (60223283..60404853, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5637 Neighboring gene mcf.2 transforming sequence Neighboring gene STARR-seq mESC enhancer starr_47238 Neighboring gene STARR-seq mESC enhancer starr_47239 Neighboring gene STARR-seq mESC enhancer starr_47240 Neighboring gene STARR-seq mESC enhancer starr_47242 Neighboring gene predicted gene, 22287 Neighboring gene microRNA 505 Neighboring gene predicted gene 8144 Neighboring gene predicted gene 7073

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes. de Waart DR, et al. Hepatology, 2016 Jul. PMID 26926206, Free PMC Article
    2. ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes. Yabas M, et al. PLoS One, 2016. PMID 26799398, Free PMC Article
    3. ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function. Naik J, et al. Dig Dis, 2015. PMID 26045263
    4. Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span. Yabas M, et al. J Biol Chem, 2014 Jul 11. PMID 24898253, Free PMC Article
    5. The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane. Takayama M, et al. J Cell Sci, 2019 Sep 2. PMID 31371488

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation.
      Title: ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation.
    2. The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane.
      Title: The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane.
    3. ATP11A and ATP11C in precursor B cells are essential for rapidly internalizing PtdSer from the cell surface to prevent the cells' engulfment by macrophages.
      Title: Phospholipid flippases enable precursor B cells to flee engulfment by macrophages.
    4. essential for basolateral membrane localization of multiple bile salt transport proteins in central hepatocytes
      Title: Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice.
    5. a mutation in ATP11C resulted in diminished flippase activity in immune cells, suggesting ATP11C is a flippase that selectively transports phosphatidylserine and phosphatidylethanolamine from the outer leaflet of the plasma membrane to the inner leaflet.
      Title: ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes.
    6. an essential role for ATP11C in erythrocyte morphology and survival and provide a new candidate for the rare inherited blood disorder stomatocytosis with uncompensated anemia.
      Title: Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span.
    7. Mutation of the X-linked gene Atp11c, which encodes a paralogous P4-type ATPase, precludes B-cell development in the adult bone marrow, but also causes hyperbilirubinemia.
      Title: X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C.
    8. A defect is ATP11C results inlower B-cell phosphatidylserine flippase activity and disrupts B-cell development and antibody production and also causes hepatocellular carcinoma.
      Title: ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes.
    9. ATP11C is redundant during B cell development in the fetal liver but essential in the context of adult bone marrow where it is required for optiml responses to IL-7 and sustained expression of Ebf1.
      Title: The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (4)  1 citation
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117487

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pre-B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase 11C
    Names
    Atpase 11c, p type
    P4-ATPase flippase complex alpha subunit ATP11C
    probable phospholipid-transporting ATPase 11C
    NP_001001798.1
    NP_001032952.1
    NP_001345931.1
    XP_006528153.1
    XP_006528154.1
    XP_006528156.1
    XP_006528158.1
    XP_006528159.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001798.3 → NP_001001798.1  phospholipid-transporting ATPase 11C isoform b

      Status: VALIDATED

      Source sequence(s)
      BC106087, BY017646, CO042050, CU682339
      Consensus CDS
      CCDS40987.1
      UniProtKB/TrEMBL
      E9QKK8, F6Q8D3
      Related
      ENSMUSP00000033480.7, ENSMUST00000033480.13
      Conserved Domains (8) summary
      TIGR01652
      Location:40 → 1088
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:97 → 182
      E1-E2_ATPase; E1-E2 ATPase
      pfam04547
      Location:260 → 374
      Anoctamin; Calcium-activated chloride channel
      pfam13246
      Location:468 → 572
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:37 → 90
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:842 → 1089
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl14615
      Location:555 → 674
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl21460
      Location:811 → 840
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_001037863.2 → NP_001032952.1  phospholipid-transporting ATPase 11C isoform a

      See identical proteins and their annotated locations for NP_001032952.1

      Status: VALIDATED

      Source sequence(s)
      BC106087, BY017646, CO042050, CU682339
      Consensus CDS
      CCDS40988.1
      UniProtKB/Swiss-Prot
      Q3KQR4, Q9QZW0
      UniProtKB/TrEMBL
      F6Q8D3
      Related
      ENSMUSP00000099066.3, ENSMUST00000101527.3
      Conserved Domains (2) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam02322
      Location:993 → 1083
      Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

    3. NM_001359002.1 → NP_001345931.1  phospholipid-transporting ATPase 11C isoform c

      Status: VALIDATED

      Source sequence(s)
      AL670778, BX284683, CO042050, CU682339
      UniProtKB/TrEMBL
      F6Q8D3
      Conserved Domains (1) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      59268643..59450041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528091.5 → XP_006528154.1  phospholipid-transporting ATPase 11C isoform X1

      See identical proteins and their annotated locations for XP_006528154.1

      UniProtKB/Swiss-Prot
      Q3KQR4, Q9QZW0
      UniProtKB/TrEMBL
      F6Q8D3
      Conserved Domains (2) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam02322
      Location:993 → 1083
      Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

    2. XM_006528090.5 → XP_006528153.1  phospholipid-transporting ATPase 11C isoform X1

      See identical proteins and their annotated locations for XP_006528153.1

      UniProtKB/Swiss-Prot
      Q3KQR4, Q9QZW0
      UniProtKB/TrEMBL
      F6Q8D3
      Conserved Domains (2) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam02322
      Location:993 → 1083
      Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

    3. XM_006528095.4 → XP_006528158.1  phospholipid-transporting ATPase 11C isoform X3

      See identical proteins and their annotated locations for XP_006528158.1

      UniProtKB/TrEMBL
      F6Q8D3
      Conserved Domains (2) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam02322
      Location:993 → 1083
      Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

    4. XM_006528093.3 → XP_006528156.1  phospholipid-transporting ATPase 11C isoform X2

      See identical proteins and their annotated locations for XP_006528156.1

      UniProtKB/TrEMBL
      F6Q8D3
      Conserved Domains (1) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    5. XM_006528096.3 → XP_006528159.1  phospholipid-transporting ATPase 11C isoform X3

      See identical proteins and their annotated locations for XP_006528159.1

      UniProtKB/TrEMBL
      F6Q8D3
      Conserved Domains (2) summary
      cd02073
      Location:42 → 974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam02322
      Location:993 → 1083
      Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

    RNA

    1. XR_001782750.2 RNA Sequence

    2. XR_004940343.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZW0.2 GenPept UniProtKB/Swiss-Prot:Q9QZW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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