dop-2 Dopamine receptor 2 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: dop-2
Gene description: Dopamine receptor 2
Primary source: WormBase:WBGene00001053
Locus tag: CELE_K09G1.4
See related: AllianceGenome:WB:WBGene00001053
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including cellular response to nicotine; cellular response to organonitrogen compound; and male mating behavior. Predicted to be located in plasma membrane and synapse. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in GLR; male-specific anatomical entity; and neurons. Used to study Parkinson's disease and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (dopamine receptor D4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See dop-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 15

Sequence:: Chromosome: V; NC_003283.11 (9608556..9614940)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This report that confinement of spicule insertion attempts to the vulva is facilitated by D2-like receptor modulation of gap-junctions between PCB and the hook sensillum.
Title: DOP-2 D2-Like Receptor Regulates UNC-7 Innexins to Attenuate Recurrent Sensory Motor Neurons during C. elegans Copulation.
Coexpressed D1- and D2-like dopamine receptors antagonistically modulate acetylcholine release in Caenorhabditis elegans.
Title: Coexpressed D1- and D2-like dopamine receptors antagonistically modulate acetylcholine release in Caenorhabditis elegans.
Dopamine signalling suppresses octopamine signalling through a mechanism that requires two D2-like dopamine receptors, DOP-2 and DOP-3, located on both the SIA neurons and RIC neurons.
Title: Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K09G1.4 (e-PCR)
- UniSTS:321580

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP Inferred from Mutant Phenotype more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuronal signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to food	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spicule insertion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, dopaminergic	IEA Inferred from Electronic Annotation more info
involved_in vulval location	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Dopamine receptor 2

NP_001024047.1

Confirmed by transcript evidence

NP_001256126.1

Confirmed by transcript evidence

NP_001256127.1

Confirmed by transcript evidence

NP_001360548.1

Confirmed by transcript evidence

NP_001360549.1

Confirmed by transcript evidence

NP_001360550.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

9608556..9614940

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269197.4 → NP_001256126.1 Dopamine receptor 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256126.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A486WWQ7, A0A486WXI1, A0A486WYH7, E7EM37, G5EBI6, G5EEM7, H2L2G2

Conserved Domains (3) summary

cd15053
Location:38 → 233

7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

cd14964
Location:751 → 781

7tm_GPCRs; TM helix 6 [structural motif]

cl28897
Location:745 → 828

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001269198.4 → NP_001256127.1 Dopamine receptor 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256127.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L2G2

Conserved Domains (3) summary

cd15053
Location:38 → 233

7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

cd14964
Location:636 → 666

7tm_GPCRs; TM helix 6 [structural motif]

cl28897
Location:630 → 713

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001028876.4 → NP_001024047.1 Dopamine receptor 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024047.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EEM7

Conserved Domains (3) summary

cd15053
Location:38 → 233

7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

cd14964
Location:610 → 635

7tm_GPCRs; TM helix 6 [structural motif]

cl28897
Location:601 → 684

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001373078.2 → NP_001360550.1 Dopamine receptor 2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

cd15053
Location:38 → 233

7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

cd14964
Location:602 → 632

7tm_GPCRs; TM helix 6 [structural motif]

cl28897
Location:596 → 679

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001373077.2 → NP_001360548.1 Dopamine receptor 2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

cd15053
Location:38 → 233

7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

cd14964
Location:631 → 661

7tm_GPCRs; TM helix 6 [structural motif]

cl28897
Location:625 → 708

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001373076.2 → NP_001360549.1 Dopamine receptor 2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

cd15053
Location:38 → 233

7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

cd14964
Location:746 → 776

7tm_GPCRs; TM helix 6 [structural motif]

cl28897
Location:740 → 823

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily