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    asp-5 Peptidase A1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179211, updated on 5-May-2024

    Summary

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    Gene symbol
    asp-5
    Gene description
    Peptidase A1 domain-containing protein
    Primary source
    WormBase:WBGene00000218
    Locus tag
    CELE_F21F8.3
    See related
    AllianceGenome:WB:WBGene00000218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in cell death. Predicted to be active in lysosome. Is expressed in intestine. Orthologous to several human genes including CTSE (cathepsin E); PGA4 (pepsinogen A4); and PGA5 (pepsinogen A5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See asp-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (8272385..8274044)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Aspartic protease 6 Neighboring gene Peptidase A1 domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6. Lochnit G, et al. Biol Chem, 2006 Oct-Nov. PMID 17081123
    2. Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1. Tcherepanova I, et al. J Biol Chem, 2000 Aug 25. PMID 10854422
    3. Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure. Mello LV, et al. BMC Genomics, 2009 Dec 16. PMID 20015380, Free PMC Article
    4. Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Syntichaki P, et al. Nature, 2002 Oct 31. PMID 12410314
    5. The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine. McGhee JD, et al. Dev Biol, 2007 Feb 15. PMID 17113066

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase A1 domain-containing protein
    NP_505135.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8272385..8274044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072734.8 → NP_505135.1  Peptidase A1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505135.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01532
      Conserved Domains (1) summary
      pfam00026
      Location:72 → 387
      Asp; Eukaryotic aspartyl protease
    Nucleotide Protein
    Heading Accession and Version

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