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    ucp3 uncoupling protein 3 [ Danio rerio (zebrafish) ]

    Gene ID: 794081, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ucp3provided by ZNC
    Official Full Name
    uncoupling protein 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1317
    See related
    Ensembl:ENSDARG00000091209 AllianceGenome:ZFIN:ZDB-GENE-040426-1317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ucp2l; zgc:63967
    Summary
    Predicted to enable oxidative phosphorylation uncoupler activity. Predicted to be involved in adaptive thermogenesis; mitochondrial transmembrane transport; and response to cold. Predicted to act upstream of or within mitochondrial transport. Predicted to be located in mitochondrial membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; eye; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See ucp3 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (36650235..36656696)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (36706477..36712938)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene remodeling and spacing factor 1b, tandem duplicate 1 Neighboring gene uncharacterized LOC110440075 Neighboring gene uncoupling protein 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals. Saito S, et al. Gene, 2008 Jan 31. PMID 18023297
    2. Enantioselective bioaccumulation following exposure of adult zebrafish (Danio rerio) to epoxiconazole and its effects on metabolomic profile as well as genes expression. Wang Y, et al. Environ Pollut, 2017 Oct. PMID 28601015
    3. Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis. Jastroch M, et al. Physiol Genomics, 2005 Jul 14. PMID 15886331
    4. An engineering approach to extending lifespan in C. elegans. Sagi D, et al. PLoS Genet, 2012. PMID 22737090, Free PMC Article
    5. Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. Dinarello A, et al. Int J Mol Sci, 2022 Feb 28. PMID 35269817, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC63967

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables oxidative phosphorylation uncoupler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive thermogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to cold IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial uncoupling protein 3
    Names
    uncoupling protein 2, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200353.2 → NP_956647.2  mitochondrial uncoupling protein 3

      See identical proteins and their annotated locations for NP_956647.2

      Status: VALIDATED

      Source sequence(s)
      AL845435, EH433128
      UniProtKB/TrEMBL
      A0A8M1PB52, A8KC25
      Related
      ENSDARP00000105553.2, ENSDART00000126963.4
      Conserved Domains (2) summary
      PTZ00169
      Location:14 → 298
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:114 → 207
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      36650235..36656696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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