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    malt2 MALT paracaspase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 259196, updated on 27-Mar-2024

    Summary

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    Official Symbol
    malt2provided by ZNC
    Official Full Name
    MALT paracaspase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020801-2
    See related
    Ensembl:ENSDARG00000006052 AllianceGenome:ZFIN:ZDB-GENE-020801-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    malt1; malt1a; pcasp2
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See malt2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (15705889..15717991, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (15679699..15691823, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene lipoprotein lipase-like Neighboring gene si:ch1073-396h14.1 Neighboring gene scaffold attachment factor B Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene family with sequence similarity 32 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Uren AG, et al. Mol Cell, 2000 Oct. PMID 11090634
    2. Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. Ung CY, et al. BMC Genomics, 2010 Mar 30. PMID 20353558, Free PMC Article
    3. MALT1 is not alone after all: identification of novel paracaspases. Hulpiau P, et al. Cell Mol Life Sci, 2016 Mar. PMID 26377317, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MALT paracaspase 2
    Names
    MALT1 paracaspase a
    mucosa associated lymphoid tissue lymphoma translocation gene 1
    mucosa associated lymphoid tissue lymphoma translocation gene 1a
    paracaspace
    paracaspase-2
    pcasp1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152976.1 → NP_694508.1  MALT paracaspase 2

      See identical proteins and their annotated locations for NP_694508.1

      Status: PROVISIONAL

      Source sequence(s)
      AF316598
      UniProtKB/TrEMBL
      A0A8M1PDS9, Q9DDL2
      Related
      ENSDARP00000020264.8, ENSDART00000008424.10
      Conserved Domains (5) summary
      smart00410
      Location:112 → 181
      IG_like; Immunoglobulin like
      pfam07679
      Location:211 → 288
      I-set; Immunoglobulin I-set domain
      cd08783
      Location:8 → 102
      Death_MALT1; Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1
      pfam00656
      Location:323 → 526
      Peptidase_C14; Caspase domain
      pfam13895
      Location:214 → 276
      Ig_2; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      15705889..15717991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161701.4 → XP_005161758.1  MALT paracaspase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B8H7
      Conserved Domains (5) summary
      smart00410
      Location:112 → 181
      IG_like; Immunoglobulin like
      pfam07679
      Location:207 → 284
      I-set; Immunoglobulin I-set domain
      cd08783
      Location:8 → 102
      Death_MALT1; Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1
      pfam00656
      Location:319 → 522
      Peptidase_C14; Caspase domain
      pfam13895
      Location:210 → 272
      Ig_2; Immunoglobulin domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395099.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      3458..15274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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