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    Pwwp3a PWWP domain containing 3A, DNA repair factor [ Mus musculus (house mouse) ]

    Gene ID: 68114, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Pwwp3aprovided by MGI
    Official Full Name
    PWWP domain containing 3A, DNA repair factorprovided by MGI
    Primary source
    MGI:MGI:1915364
    See related
    Ensembl:ENSMUSG00000020156 AllianceGenome:MGI:1915364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mum1; MUM-1; UBE-1C2; 2610019J09; 9430059D04Rik
    Summary
    Predicted to enable nucleosome binding activity. Predicted to be involved in DNA repair and chromatin organization. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including foregut; ganglia; midbrain lateral wall; nose; and tooth. Orthologous to human PWWP3A (PWWP domain containing 3A, DNA repair factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 52.6), CNS E11.5 (RPKM 26.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pwwp3a in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80062265..80082415)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80226431..80245144)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E576 Neighboring gene family with sequence similarity 174, member C Neighboring gene ephrin A2 Neighboring gene STARR-positive B cell enhancer ABC_E3898 Neighboring gene nuclear encoded tRNA pheylalanine 3 (anticodon GAA) Neighboring gene nuclear encoded tRNA asparagine 7 (anticodon GTT) Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PWWP domain-containing DNA repair factor 3A
    Names
    PWWP domain-containing protein MUM1
    melanoma associated antigen (mutated) 1
    mutated melanoma-associated antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023431.6 → NP_075920.4  PWWP domain-containing DNA repair factor 3A

      See identical proteins and their annotated locations for NP_075920.4

      Status: VALIDATED

      Source sequence(s)
      AC140229
      Consensus CDS
      CCDS24014.1
      UniProtKB/Swiss-Prot
      Q3TCZ4, Q6DID5, Q6NST9, Q8C5E3, Q8R1V6, Q9R1R7
      Related
      ENSMUSP00000020365.9, ENSMUST00000020365.15
      Conserved Domains (1) summary
      cd06080
      Location:381 → 460
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80062265..80082415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245246.1 → XP_030101106.1  PWWP domain-containing DNA repair factor 3A isoform X1

      UniProtKB/Swiss-Prot
      Q3TCZ4, Q6DID5, Q6NST9, Q8C5E3, Q8R1V6, Q9R1R7
      Conserved Domains (1) summary
      cd06080
      Location:381 → 460
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    2. XM_006514026.2 → XP_006514089.1  PWWP domain-containing DNA repair factor 3A isoform X2

      Conserved Domains (1) summary
      cd06080
      Location:381 → 460
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    3. XM_006514025.3 → XP_006514088.1  PWWP domain-containing DNA repair factor 3A isoform X1

      See identical proteins and their annotated locations for XP_006514088.1

      UniProtKB/Swiss-Prot
      Q3TCZ4, Q6DID5, Q6NST9, Q8C5E3, Q8R1V6, Q9R1R7
      Conserved Domains (1) summary
      cd06080
      Location:381 → 460
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DID5.1 GenPept UniProtKB/Swiss-Prot:Q6DID5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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