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    Set [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41844, updated on 10-May-2024

    Summary

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    Official Symbol
    Setprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014879
    Locus tag
    Dmel_CG4299
    See related
    AllianceGenome:FB:FBgn0014879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4299; Dmel\CG4299; dSet; dSET; SET; TAF-Ibeta
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in nucleosome assembly. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; germ layer; presumptive embryonic/larval central nervous system; and ventral ectoderm anlage. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability; gonadal dysgenesis; and sudden infant death syndrome. Orthologous to several human genes including SET (SET nuclear proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Set in Genome Data Viewer
    Location:
    88E8-88E8; 3-56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15263552..15265253)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11089274..11090975)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2 subunit gamma Neighboring gene Suppressor of variegation 3-9 Neighboring gene ATP synthase, oligomycin sensitivity conferring protein Neighboring gene uncharacterized protein Neighboring gene Zinc/iron regulated transporter-related protein 88E Neighboring gene Centrosomal protein 190kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ. Kim DW, et al. Biochem Biophys Res Commun, 2010 Sep 24. PMID 20800572
    2. Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity. Kim JY, et al. Nucleic Acids Res, 2012 Jan. PMID 21911363, Free PMC Article
    3. Members of the NAP/SET family of proteins interact specifically with B-type cyclins. Kellogg DR, et al. J Cell Biol, 1995 Aug. PMID 7622566, Free PMC Article
    4. A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo. Ng T, et al. Dev Genes Evol, 2006 May. PMID 16506071
    5. The Drosophila SET domain encoding gene dEset is essential for proper development. Stabell M, et al. Hereditas, 2006 Dec. PMID 17362353

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A homologue of the vertebrate SET domain regulates terminal differentiation of the tracheal system in the Drosophila embryo.
      Title: A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.
    2. By using spatio-temporal RNA interference we show that dEset is required at several stages of development coinciding with ecdysone pulses, possibly as a repressor of transcription of target genes
      Title: The Drosophila SET domain encoding gene dEset is essential for proper development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Set
    Names
    CG4299-PA
    Set-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15263552..15265253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142181.3 → NP_650438.2  Set [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650438.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53997, Q540W9, Q9VFA5
      Related
      FBpp0082521
      Conserved Domains (1) summary
      pfam00956
      Location:31 → 227
      NAP; Nucleosome assembly protein (NAP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53997.2 P53997

    Gene LinkOut

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