U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Spn88Ea Serpin 88Ea [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49804, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Spn88Eaprovided by FlyBase
    Official Full Name
    Serpin 88Eaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028984
    Locus tag
    Dmel_CG18525
    See related
    AllianceGenome:FB:FBgn0028984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18525; Dmel\CG18525; sp5; Sp5; spn5; Spn5
    Summary
    Involved in several processes, including imaginal disc-derived wing expansion; negative regulation of Toll signaling pathway; and negative regulation of innate immune response. Located in extracellular region. Is expressed in several structures, including embryonic epidermis; embryonic/larval garland cell; embryonic/larval tracheal system; gut section; and ovary. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); lung disease (multiple); and thrombophilia (multiple). Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINC1 (serpin family C member 1); and SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Spn88Ea in Genome Data Viewer
    Location:
    88E3-88E3; 3-56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15203069..15206447, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11028791..11032169, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Guanylyl cyclase at 88E Neighboring gene Myofilin Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1 Neighboring gene uncharacterized protein Neighboring gene Serpin 88Eb Neighboring gene Mau2 sister chromatid cohesion factor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The serpin Spn5 is essential for wing expansion in Drosophila melanogaster. Charron Y, et al. Int J Dev Biol, 2008. PMID 18956323
    2. A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade. Colinet D, et al. Dev Comp Immunol, 2009 May. PMID 19109990
    3. A novel Drosophila serpin that inhibits serine proteases. Han J, et al. FEBS Lett, 2000 Feb 25. PMID 10692585
    4. Elimination of oncogenic cells that regulate epithelial homeostasis in Drosophila. Ohsawa S. Dev Growth Differ, 2019 Jun. PMID 30957223, Free PMC Article
    5. Spatial regulation of developmental signaling by a serpin. Hashimoto C, et al. Dev Cell, 2003 Dec. PMID 14667416

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study suggests that Spn5 secreted from normal epithelial cells acts as a component of the extracellular surveillance system that facilitates elimination of pre-malignant cells from epithelium.
      Title: Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila.
    2. Spn5 is a regulator of the Toll pathway and CHMP2B toxicity and the Toll pathway is a major signaling pathway misregulated by mutant CHMP2B in vivo.
      Title: Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia.
    3. Spn5 is essential for wing expansion in Drosophila melanogaster.
      Title: The serpin Spn5 is essential for wing expansion in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived wing expansion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serpin 88Ea
    Names
    CG18525-PA
    CG18525-PB
    Dm-serpin-88Ea
    Spn88Ea-PA
    Spn88Ea-PB
    serine protease inhibitor 5
    serpin
    serpin 5
    serpin5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15203069..15206447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176501.3 → NP_788678.1  serpin 88Ea, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788678.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U1I4, Q9VFC2
      Related
      FBpp0082596
      Conserved Domains (1) summary
      cd00172
      Location:39 → 419
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_080215.4 → NP_524954.2  serpin 88Ea, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524954.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U1I4, Q9VFC2
      Related
      FBpp0082595
      Conserved Domains (1) summary
      cd00172
      Location:39 → 419
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFC2.1 Q9VFC2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous