Msrb2 methionine sulfoxide reductase B2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Msrb2provided by MGI
Official Full Name: methionine sulfoxide reductase B2provided by MGI
Primary source: MGI:MGI:1923717
See related: Ensembl:ENSMUSG00000023094 AllianceGenome:MGI:1923717
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mrsb; Msrb; Pilb; 2310050L06Rik
Summary: Enables actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Involved in actin filament polymerization. Acts upstream of or within protein repair. Located in mitochondrion. Is expressed in several structures, including brown fat; heart; inner ear; skeletal muscle; and testis. Orthologous to human MSRB2 (methionine sulfoxide reductase B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 10.8), kidney adult (RPKM 6.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 13.26 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (19376247..19399787)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (19371436..19394976)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Release of the enzyme MsrB2 from damaged mitochondria, initiating autophagosome formation, represents a novel regulatory mechanism for oxidative stress-induced mitophagy.
Title: Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.
the role for mitochondrial MSRB2 in Alzheimer's disease pathology is indispensible.
Title: Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology.
Data show that glutaredoxin acts as a reductant for methionine sulfoxide reductases A and B (MsrA and MsrB) with or without resolving cysteine.
Title: Glutaredoxin serves as a reductant for methionine sulfoxide reductases with or without resolving cysteine.
overall structure is composed of two beta-sheets consisting of eight antiparallel beta-strands and three N-terminal alpha-helices and is more similar to those of bacterial MsrBs than to that of mammalian MsrB1
Title: Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2.
Studies show all Met sulfoxide residues in an MRP can be reduced by MsrA and MsrB.
Title: Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms.
MsrA and MsrB2, the two proteins with similar function in antioxidant protein repair, have different effects on aging in fruit flies.
Title: Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.
Results show that mammalian MsrB and MsrA proteins perform crucial functions in protection against oxidative stress in lower eukaryotic yeast cells.
Title: Expression, subcellular localization, and antioxidant role of mammalian methionine sulfoxide reductases in Saccharomyces cerevisiae.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Markers

31.MMHAP91FLC4.seq (e-PCR)
- UniSTS:123964

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-methionine-(R)-S-oxide reductase activity	IEA Inferred from Electronic Annotation more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IEA Inferred from Electronic Annotation more info
enables peptide-methionine (R)-S-oxide reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-methionine (R)-S-oxide reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein repair	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: methionine-R-sulfoxide reductase B2, mitochondrial

Names: pilin-like transcription factor

NP_083895.1

EC 1.8.4.12

EC 1.8.4.14

XP_006497626.1

EC 1.8.4.12

EC 1.8.4.14

XP_017174809.1

EC 1.8.4.12

EC 1.8.4.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029619.2 → NP_083895.1 methionine-R-sulfoxide reductase B2, mitochondrial precursor

See identical proteins and their annotated locations for NP_083895.1

Status: PROVISIONAL

Source sequence(s)

BC021619

Consensus CDS

CCDS15714.1

UniProtKB/Swiss-Prot

Q78J03

Related

ENSMUSP00000023856.9, ENSMUST00000023856.9

Conserved Domains (1) summary

PRK00222
Location:43 → 172

PRK00222; methionine sulfoxide reductase B; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

19376247..19399787

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319320.2 → XP_017174809.1 methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

Conserved Domains (1) summary

cl15841
Location:124 → 150

SelR; SelR domain
XM_006497563.3 → XP_006497626.1 methionine-R-sulfoxide reductase B2, mitochondrial isoform X2

Conserved Domains (1) summary

pfam01641
Location:18 → 144

SelR; SelR domain