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    Nudt17 nudix hydrolase 17 [ Mus musculus (house mouse) ]

    Gene ID: 78373, updated on 25-May-2024

    Summary

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    Official Symbol
    Nudt17provided by MGI
    Official Full Name
    nudix hydrolase 17provided by MGI
    Primary source
    MGI:MGI:1925623
    See related
    Ensembl:ENSMUSG00000028100 AllianceGenome:MGI:1925623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410015C20Rik
    Summary
    Predicted to enable NADH pyrophosphatase activity. Predicted to be involved in NAD catabolic process; NADH metabolic process; and NADP catabolic process. Predicted to be active in peroxisome. Orthologous to human NUDT17 (nudix hydrolase 17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 3.2), thymus adult (RPKM 2.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nudt17 in Genome Data Viewer
    Location:
    3 F2.1; 3 41.95 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96613208..96616233, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96705892..96708916, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21, pseudogene 11 Neighboring gene STARR-positive B cell enhancer ABC_E6084 Neighboring gene STARR-seq mESC enhancer starr_08444 Neighboring gene ankyrin repeat domain 35 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide C Neighboring gene STARR-positive B cell enhancer ABC_E6085 Neighboring gene predicted gene, 22581 Neighboring gene ring finger protein 115

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
    5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADH pyrophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADH metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleoside diphosphate-linked moiety X motif 17
    Names
    nudix (nucleoside diphosphate linked moiety X)-type motif 17
    nudix motif 17
    NP_001156397.1
    NP_084370.1
    XP_006502379.1
    XP_006502380.1
    XP_030108761.1
    XP_030108762.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162925.1 → NP_001156397.1  nucleoside diphosphate-linked moiety X motif 17 isoform 2

      See identical proteins and their annotated locations for NP_001156397.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame coding exon compared to variant 1, resulting in a longer isoform (2) with a different internal protein segment compared to isoform 1.
      Source sequence(s)
      AC112261, AK019109, AK134929
      Consensus CDS
      CCDS51009.1
      UniProtKB/Swiss-Prot
      Q9CWD3
      Related
      ENSMUSP00000029742.6, ENSMUST00000029742.9
      Conserved Domains (1) summary
      cl00447
      Location:92 → 251
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    2. NM_030094.1 → NP_084370.1  nucleoside diphosphate-linked moiety X motif 17 isoform 1

      See identical proteins and their annotated locations for NP_084370.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      AK019109, AK134929
      Consensus CDS
      CCDS51008.1
      UniProtKB/Swiss-Prot
      Q14BX3, Q3URR9, Q9CWD3
      Related
      ENSMUSP00000129851.2, ENSMUST00000171249.6
      Conserved Domains (1) summary
      cl00447
      Location:92 → 234
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96613208..96616233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252901.2 → XP_030108761.1  nucleoside diphosphate-linked moiety X motif 17 isoform X3

      Conserved Domains (1) summary
      cl00447
      Location:40 → 148
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    2. XM_030252902.2 → XP_030108762.1  nucleoside diphosphate-linked moiety X motif 17 isoform X3

      Conserved Domains (1) summary
      cl00447
      Location:40 → 148
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    3. XM_006502316.5 → XP_006502379.1  nucleoside diphosphate-linked moiety X motif 17 isoform X1

      Conserved Domains (1) summary
      cl00447
      Location:79 → 238
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    4. XM_006502317.5 → XP_006502380.1  nucleoside diphosphate-linked moiety X motif 17 isoform X2

      Conserved Domains (1) summary
      cl00447
      Location:79 → 221
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWD3.1 GenPept UniProtKB/Swiss-Prot:Q9CWD3

    Gene LinkOut

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