Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfsf13provided by MGI
Official Full Name: tumor necrosis factor (ligand) superfamily, member 13provided by MGI
Primary source: MGI:MGI:1916833
See related: Ensembl:ENSMUSG00000089669 AllianceGenome:MGI:1916833
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: April; Tall2; Trdl1; Tnlg7b; 2310026N09Rik
Summary: Predicted to enable receptor ligand activity. Acts upstream of or within immunoglobulin mediated immune response; positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and positive regulation of cell population proliferation. Located in external side of plasma membrane. Is expressed in central nervous system; renal vasculature; retina outer nuclear layer; and superior cervical ganglion. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma. Orthologous to human TNFSF13 (TNF superfamily member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 9.6), colon adult (RPKM 8.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.86 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69573403..69576380, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69682577..69685554, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anti-inflammatory role of APRIL by modulating regulatory B cells in antigen-induced arthritis.
Title: Anti-inflammatory role of APRIL by modulating regulatory B cells in antigen-induced arthritis.
BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth.
Title: BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth.
Spatial heterogeneity for APRIL production by eosinophils in the small intestine.
Title: Spatial heterogeneity for APRIL production by eosinophils in the small intestine.
A BAFF/APRIL axis regulates obesogenic diet-driven weight gain.
Title: A BAFF/APRIL axis regulates obesogenic diet-driven weight gain.
Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-kappaB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells.
Title: Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells.
APRIL Induces a Novel Subset of IgA(+) Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1.
Title: APRIL Induces a Novel Subset of IgA(+) Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1.
Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells.
Title: Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells.
Data show that APRIL mediates an anti-inflammatory response from astrocytes in multiple sclerosis lesions. This protective activity is not shared with BAFF.
Title: A proliferation-inducing ligand-mediated anti-inflammatory response of astrocytes in multiple sclerosis.
p40, a Lactobacillus rhamnosus-derived protein upregulates EGFR-dependent APRIL expression in intestinal epithelial cells, which may contribute to promoting IgA production
Title: An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells.
this study identifies APRIL as a new target involved in B-cell activation, in the maintenance of plasma cell survival and subsequent increased autoantibody production that sustains lupus development in mice
Title: TACI-dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosus.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Readthrough Tnfsfm13

Readthrough gene: Tnfsfm13, Included gene: Tnfsf12

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of germinal center formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunoglobulin production in mucosal tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of germinal center formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of isotype switching to IgA isotypes	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of isotype switching to IgA isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of isotype switching to IgA isotypes	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 13

Names: a proliferation-inducing ligand; tumor necrosis factor ligand 7b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159505.1 → NP_001152977.1 tumor necrosis factor ligand superfamily member 13 isoform 2

See identical proteins and their annotated locations for NP_001152977.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal aa, compared to isoform 1.

Source sequence(s)

AK009514, AK134028, AL603707

Consensus CDS

CCDS48827.1

UniProtKB/TrEMBL

A0A0U5J5N9, Q5F2A4

Related

ENSMUSP00000018896.8, ENSMUST00000018896.14

Conserved Domains (1) summary

cd00184
Location:108 → 238

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
NM_023517.2 → NP_076006.2 tumor necrosis factor ligand superfamily member 13 isoform 1

See identical proteins and their annotated locations for NP_076006.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK009514, AK134028, BY463961

UniProtKB/Swiss-Prot

Q9D777, Q9ERP1

UniProtKB/TrEMBL

A0A0U5J5N9

Conserved Domains (1) summary

cd00184
Location:108 → 239

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...