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    Mindy4 MINDY lysine 48 deubiquitinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 330323, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Mindy4provided by MGI
    Official Full Name
    MINDY lysine 48 deubiquitinase 4provided by MGI
    Primary source
    MGI:MGI:3583959
    See related
    Ensembl:ENSMUSG00000038022 AllianceGenome:MGI:3583959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1406; Fam188b; C330043M08Rik
    Summary
    Predicted to enable Lys48-specific deubiquitinase activity. Predicted to act upstream of or within proteolysis. Orthologous to human MINDY4 (MINDY lysine 48 deubiquitinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 10.7), lung adult (RPKM 3.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mindy4 in Genome Data Viewer
    Location:
    6 B3; 6 27.38 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (55180337..55297208)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (55203350..55320223)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15973 Neighboring gene predicted gene, 34358 Neighboring gene indolethylamine N-methyltransferase Neighboring gene predicted gene, 38819 Neighboring gene aquaporin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
    2. Identification of 14-3-3epsilon substrates from embryonic murine brain. Ballif BA, et al. J Proteome Res, 2006 Sep. PMID 16944949
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K48-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    probable ubiquitin carboxyl-terminal hydrolase MINDY-4
    Names
    family with sequence similarity 188, member B
    probable deubiquitinating enzyme MINDY-4
    probable ubiquitin carboxyl-terminal hydrolase FAM188B
    protein FAM188B
    NP_001136253.1
    NP_808551.2
    XP_006506359.1
    XP_006506361.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142781.1 → NP_001136253.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform 1

      See identical proteins and their annotated locations for NP_001136253.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK082855, AK142385
      Consensus CDS
      CCDS51782.1
      UniProtKB/Swiss-Prot
      Q3UQI9, Q8C472
      Related
      ENSMUSP00000061221.8, ENSMUST00000053094.8
      Conserved Domains (1) summary
      pfam13898
      Location:403 → 739
      DUF4205; Domain of unknown function (DUF4205)

    2. NM_177883.4 → NP_808551.2  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK082855, AK161304
      Consensus CDS
      CCDS85054.1
      UniProtKB/TrEMBL
      A0A0N4SVL4
      Related
      ENSMUSP00000145151.2, ENSMUST00000204842.3
      Conserved Domains (1) summary
      pfam13898
      Location:403 → 527
      DUF4205; Domain of unknown function (DUF4205)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      55180337..55297208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506298.5 → XP_006506361.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X2

      UniProtKB/TrEMBL
      Q0VF82

    2. XM_006506296.4 → XP_006506359.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X1

      Conserved Domains (1) summary
      pfam13898
      Location:403 → 685
      DUF4205; Domain of unknown function (DUF4205)

    RNA

    1. XR_004942977.1 RNA Sequence

    2. XR_003956212.2 RNA Sequence

    3. XR_004942976.1 RNA Sequence

    4. XR_003956211.2 RNA Sequence

    5. XR_003956214.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UQI9.1 GenPept UniProtKB/Swiss-Prot:Q3UQI9

    Gene LinkOut

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