Lrfn3 leucine rich repeat and fibronectin type III domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrfn3provided by MGI
Official Full Name: leucine rich repeat and fibronectin type III domain containing 3provided by MGI
Primary source: MGI:MGI:2442512
See related: Ensembl:ENSMUSG00000036957 AllianceGenome:MGI:2442512
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SALM4; A530045B06Rik
Summary: Predicted to be involved in regulation of presynapse assembly; regulation of synaptic membrane adhesion; and synaptic membrane adhesion. Predicted to act upstream of or within cell adhesion. Located in cell surface. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human LRFN3 (leucine rich repeat and fibronectin type III domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 16.8), duodenum adult (RPKM 14.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 17.41 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30054939..30062197, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30355514..30362772, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SALM4 negatively regulates NMDA receptor function and fear memory consolidation.
Title: SALM4 negatively regulates NMDA receptor function and fear memory consolidation.
SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation.
Title: SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.
Data show that the C-terminal PDZ binding domains of synaptic adhesion-like molecules (SALMs)1-3 are required for neurite outgrowth, and that the N-termini of SALMs 2 and 4 are alsoinvolved in neurite outgrowth.
Title: Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Markers

Lrfn3 (e-PCR), detects polymorphism
- UniSTS:525547

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeat and fibronectin type-III domain-containing protein 3

Names: synaptic adhesion-like molecule 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175478.2 → NP_780687.1 leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor

See identical proteins and their annotated locations for NP_780687.1

Status: PROVISIONAL

Source sequence(s)

AC149067

Consensus CDS

CCDS21088.1

UniProtKB/Swiss-Prot

Q505E2, Q8BLY3

Related

ENSMUSP00000037616.6, ENSMUST00000046351.7

Conserved Domains (6) summary

COG4886
Location:63 → 222

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:242 → 253

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:63 → 84

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:425 → 502

fn3; Fibronectin type III domain

cl11960
Location:310 → 383

Ig; Immunoglobulin domain

cl15307
Location:249 → 281

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain