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    Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306103, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dis3provided by RGD
    Official Full Name
    DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by RGD
    Primary source
    RGD:1304646
    See related
    Ensembl:ENSRNOG00000009125 AllianceGenome:RGD:1304646
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304646
    Summary
    Predicted to enable 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in CUT catabolic process and rRNA catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 120.8), Spleen (RPKM 102.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dis3 in Genome Data Viewer
    Location:
    15q21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (82231922..82258299, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (75820040..75850450, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (83466330..83494107, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097059 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene bora, aurora kinase A activator Neighboring gene Spi-C transcription factor, pseudogene 2 Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene KLF transcription factor 5 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3. Shiomi T, et al. J Biochem, 1998 May. PMID 9562621
    2. RNA exosome depletion reveals transcription upstream of active human promoters. Preker P, et al. Science, 2008 Dec 19. PMID 19056938
    3. Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells. Slomovic S, et al. Proc Natl Acad Sci U S A, 2010 Apr 20. PMID 20368444, Free PMC Article
    4. Dis3-like 1: a novel exoribonuclease associated with the human exosome. Staals RH, et al. EMBO J, 2010 Jul 21. PMID 20531389, Free PMC Article
    5. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Tomecki R, et al. EMBO J, 2010 Jul 21. PMID 20531386, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CUT catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in nuclear mRNA surveillance of mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    exosome complex exonuclease RRP44
    Names
    DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
    DIS3 mitotic control homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127483.1 → NP_001120955.1  exosome complex exonuclease RRP44

      See identical proteins and their annotated locations for NP_001120955.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166824
      UniProtKB/TrEMBL
      B2RYL7, F7EPZ4
      Related
      ENSRNOP00000029411.5, ENSRNOT00000037588.7
      Conserved Domains (3) summary
      cd09862
      Location:9 → 196
      PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
      COG0557
      Location:194 → 929
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:466 → 794
      RNB; RNB domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      82231922..82258299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770869.4 → XP_008769091.1  exosome complex exonuclease RRP44 isoform X3

      UniProtKB/TrEMBL
      F7EPZ4
      Conserved Domains (3) summary
      COG0557
      Location:164 → 899
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:436 → 764
      RNB; RNB domain
      cl14812
      Location:9 → 166
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    2. XM_017599715.3 → XP_017455204.1  exosome complex exonuclease RRP44 isoform X1

      UniProtKB/TrEMBL
      A6HU57

    3. XM_039093378.2 → XP_038949306.1  exosome complex exonuclease RRP44 isoform X2

      UniProtKB/TrEMBL
      A6HU57
      Conserved Domains (2) summary
      COG0557
      Location:33 → 768
      VacB; Exoribonuclease R [Transcription]
      cl28905
      Location:3 → 35
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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