marcksl1a MARCKS-like 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: marcksl1aprovided by ZNC
Official Full Name: MARCKS-like 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2146
See related: Ensembl:ENSDARG00000039034 AllianceGenome:ZFIN:ZDB-GENE-040426-2146
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MLP; cb575; marcks1; marcksl1; sb:cb575; marcksl1b; zgc:65840; wu:fa66h03; wu:fj18a04
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within cartilage development; central nervous system development; and neural retina development. Predicted to be located in cytoskeleton and membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; head mesenchyme; nervous system; and neural plate. Orthologous to human MARCKSL1 (MARCKS like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (46177506..46180510)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (46040882..46043886)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size.
Title: Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size.

Submit: New GeneRIF Correction

General gene information

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Markers

fj18a04.x1 (e-PCR)
- UniSTS:198679

fa66h03 (e-PCR)
- UniSTS:188849

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel lumenization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MARCKS-related protein 1-A

Names: MARCKS-like 1; MARCKS-like protein 1-A; MARCKS-like protein 1-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.