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    Aurkaip1 aurora kinase A interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298687, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Aurkaip1provided by RGD
    Official Full Name
    aurora kinase A interacting protein 1provided by RGD
    Primary source
    RGD:1303211
    See related
    Ensembl:ENSRNOG00000018691 AllianceGenome:RGD:1303211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akip
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity and kinase activity. Predicted to be involved in phosphorylation; regulation of catalytic activity; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of proteolysis. Predicted to be located in mitochondrion and nucleoplasm. Orthologous to human AURKAIP1 (aurora kinase A interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 239.5), Kidney (RPKM 233.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aurkaip1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171717349..171719123)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166435177..166436888)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173274433..173276170)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cyclin L2 Neighboring gene uncharacterized LOC134487049 Neighboring gene uncharacterized LOC134487050 Neighboring gene matrix remodeling associated 8 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste 1 receptor member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. Kiat LS, et al. J Biol Chem, 2002 Nov 22. PMID 12244051
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94202

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein mS38
    Names
    aurora kinase A-interacting protein
    aurora-A kinase interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004237.1 → NP_001004237.1  small ribosomal subunit protein mS38

      See identical proteins and their annotated locations for NP_001004237.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079171
      UniProtKB/TrEMBL
      F7EYT4, Q6AY68
      Conserved Domains (1) summary
      pfam08213
      Location:128 → 160
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171717349..171719123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239547.4 → XP_006239609.1  small ribosomal subunit protein mS38 isoform X2

      See identical proteins and their annotated locations for XP_006239609.1

      UniProtKB/TrEMBL
      F7EYT4, Q6AY68
      Related
      ENSRNOP00000025952.3
      Conserved Domains (1) summary
      pfam08213
      Location:128 → 160
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    2. XM_063287505.1 → XP_063143575.1  small ribosomal subunit protein mS38 isoform X3

    3. XM_063287503.1 → XP_063143573.1  small ribosomal subunit protein mS38 isoform X2

      UniProtKB/TrEMBL
      F7EYT4, Q6AY68

    4. XM_006239546.4 → XP_006239608.1  small ribosomal subunit protein mS38 isoform X2

      See identical proteins and their annotated locations for XP_006239608.1

      UniProtKB/TrEMBL
      F7EYT4, Q6AY68
      Conserved Domains (1) summary
      pfam08213
      Location:128 → 160
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    5. XM_063287504.1 → XP_063143574.1  small ribosomal subunit protein mS38 isoform X2

      UniProtKB/TrEMBL
      F7EYT4, Q6AY68

    6. XM_006239548.3 → XP_006239610.1  small ribosomal subunit protein mS38 isoform X2

      See identical proteins and their annotated locations for XP_006239610.1

      UniProtKB/TrEMBL
      F7EYT4, Q6AY68
      Conserved Domains (1) summary
      pfam08213
      Location:128 → 160
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    7. XM_008764351.3 → XP_008762573.1  small ribosomal subunit protein mS38 isoform X2

      See identical proteins and their annotated locations for XP_008762573.1

      UniProtKB/TrEMBL
      F7EYT4, Q6AY68
      Conserved Domains (1) summary
      pfam08213
      Location:128 → 160
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    8. XM_063287502.1 → XP_063143572.1  small ribosomal subunit protein mS38 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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