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    Pkib cAMP-dependent protein kinase inhibitor beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24678, updated on 24-Apr-2024

    Summary

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    Official Symbol
    Pkibprovided by RGD
    Official Full Name
    cAMP-dependent protein kinase inhibitor betaprovided by RGD
    Primary source
    RGD:3335
    See related
    Ensembl:ENSRNOG00000000811 AllianceGenome:RGD:3335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PKINH; Prkacn2; RATPKINH
    Summary
    Predicted to enable cAMP-dependent protein kinase inhibitor activity. Predicted to be involved in negative regulation of cAMP-dependent protein kinase activity and positive regulation of DNA metabolic process. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKIB (cAMP-dependent protein kinase inhibitor beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 80.8), Spleen (RPKM 48.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pkib in Genome Data Viewer
    Location:
    20q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (37511564..37608607)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (36965172..37062190)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (40616868..40712598)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 2 Neighboring gene serine incorporator 1 Neighboring gene uncharacterized LOC134483929 Neighboring gene fatty acid binding protein 7 Neighboring gene sphingomyelin phosphodiesterase, acid-like 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A dual-specificity isoform of the protein kinase inhibitor PKI produced by alternate gene splicing. Kumar P, et al. Biochem J, 2002 Mar 15. PMID 11879178, Free PMC Article
    2. Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase. Van Patten SM, et al. Proc Natl Acad Sci U S A, 1991 Jun 15. PMID 2052616, Free PMC Article
    3. Regulation of FSH receptor, PKIbeta, IL-6 and calcium mobilization: Possible mediators of differential action of FSH. Dahia CL, et al. Mol Cell Endocrinol, 2006 Mar 9. PMID 16406266
    4. Correlation between genetic and cytogenetic maps of the rat. Andoh Y, et al. Mamm Genome, 1998 Apr. PMID 9530624
    5. Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor. Baude EJ, et al. J Biol Chem, 1994 Jan 21. PMID 7905001

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PKIbeta and calcium, which are the downstream signaling molecules, are involved in FSH regulated Sertoli cells proliferation.
      Title: Regulation of FSH receptor, PKIbeta, IL-6 and calcium mobilization: Possible mediators of differential action of FSH.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of telomere capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase inhibitor beta
    Names
    PKI-beta
    cAMP-dependent protein kinase (catalytic subunit binding) inhibtor 2
    protein kinase (cAMP-dependent, catalytic) inhibitor beta
    protein kinase inhibitor beta, (cAMP-dependent, catalytic) inhibitor beta
    protein kinase inhibitor beta, cAMP dependent, catalytic
    protein kinase inhibitor beta, cAMP dependent, testis specific
    protein kinase inhibitor, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076553.2 → NP_001070021.1  cAMP-dependent protein kinase inhibitor beta isoform 1

      See identical proteins and their annotated locations for NP_001070021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC078880, BG666532, BG668634, FQ231722
      UniProtKB/TrEMBL
      F6Q5H6, Q8R4R3
      Related
      ENSRNOP00000001075.2, ENSRNOT00000001075.6
      Conserved Domains (1) summary
      pfam02827
      Location:40 → 108
      PKI; cAMP-dependent protein kinase inhibitor

    2. NM_001271158.1 → NP_001258087.1  cAMP-dependent protein kinase inhibitor beta isoform 2

      See identical proteins and their annotated locations for NP_001258087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' non-coding exon and lacks an internal exon compared to variant 1, which results in translation initiation from an in-frame downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      BC078880, FQ231722
      UniProtKB/Swiss-Prot
      P27775
      UniProtKB/TrEMBL
      A0A0G2K371, A6K4C9, Q6AYW3
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    3. NM_001429406.1 → NP_001416335.1  cAMP-dependent protein kinase inhibitor beta isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    4. NM_012627.3 → NP_036759.2  cAMP-dependent protein kinase inhibitor beta isoform 2

      See identical proteins and their annotated locations for NP_036759.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon compared to variant 1, which results in translation initiation from an in-frame downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      BC078880, BG666532, FQ231722
      UniProtKB/Swiss-Prot
      P27775
      UniProtKB/TrEMBL
      A0A0G2K371, A6K4C9, Q6AYW3
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      37511564..37608607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256513.5 → XP_006256575.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      See identical proteins and their annotated locations for XP_006256575.1

      UniProtKB/TrEMBL
      F6Q5H6, Q8R4R3
      Conserved Domains (1) summary
      pfam02827
      Location:40 → 108
      PKI; cAMP-dependent protein kinase inhibitor

    2. XM_063278957.1 → XP_063135027.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      UniProtKB/TrEMBL
      F6Q5H6, Q8R4R3

    3. XM_006256512.5 → XP_006256574.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      See identical proteins and their annotated locations for XP_006256574.1

      UniProtKB/TrEMBL
      F6Q5H6, Q8R4R3
      Conserved Domains (1) summary
      pfam02827
      Location:40 → 108
      PKI; cAMP-dependent protein kinase inhibitor

    4. XM_063278958.1 → XP_063135028.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      UniProtKB/TrEMBL
      F6Q5H6, Q8R4R3

    5. XM_039098416.2 → XP_038954344.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      UniProtKB/TrEMBL
      F6Q5H6, Q8R4R3
      Conserved Domains (1) summary
      pfam02827
      Location:40 → 108
      PKI; cAMP-dependent protein kinase inhibitor

    6. XM_006256511.5 → XP_006256573.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      See identical proteins and their annotated locations for XP_006256573.1

      UniProtKB/TrEMBL
      F6Q5H6, Q8R4R3
      Conserved Domains (1) summary
      pfam02827
      Location:40 → 108
      PKI; cAMP-dependent protein kinase inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27775.2 GenPept UniProtKB/Swiss-Prot:P27775

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