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    Coq10a coenzyme Q10A [ Mus musculus (house mouse) ]

    Gene ID: 210582, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Coq10aprovided by MGI
    Official Full Name
    coenzyme Q10Aprovided by MGI
    Primary source
    MGI:MGI:2684847
    See related
    Ensembl:ENSMUSG00000039914 AllianceGenome:MGI:2684847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1
    Summary
    Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration and ubiquinone biosynthetic process. Predicted to be active in mitochondrion. Is expressed in liver; nervous system; retina nuclear layer; and testis. Orthologous to human COQ10A (coenzyme Q10A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 68.0), adrenal adult (RPKM 25.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Coq10a in Genome Data Viewer
    Location:
    10 D3; 10 76.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128198965..128204849, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128363096..128370056, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene canopy FGF signaling regulator 2 Neighboring gene STARR-positive B cell enhancer ABC_E9813 Neighboring gene STARR-positive B cell enhancer ABC_E1134 Neighboring gene STARR-positive B cell enhancer ABC_E11467 Neighboring gene citrate synthase Neighboring gene predicted gene, 23182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127806017-127806126 Neighboring gene ankyrin repeat domain 52 Neighboring gene microRNA 6914 Neighboring gene microRNA 6915

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway. Jing L, et al. Int J Biol Sci, 2015. PMID 25552930, Free PMC Article
    2. Lysosomal accumulation of Trk protein in brain of GM₁ -gangliosidosis mouse and its restoration by chemical chaperone. Takamura A, et al. J Neurochem, 2011 Aug. PMID 21574998
    3. The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Xu M, et al. Development, 2021 Apr 15. PMID 33913477
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway.
      Title: Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC182861, MGC182867

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coenzyme Q-binding protein COQ10 homolog A, mitochondrial
    Names
    coenzyme Q10 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081040.2 → NP_001074509.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC090489
      Consensus CDS
      CCDS36089.1
      UniProtKB/TrEMBL
      E9Q3H6
      Related
      ENSMUSP00000036213.6, ENSMUST00000043211.7
      Conserved Domains (1) summary
      cd07813
      Location:89 → 237
      COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

    2. NM_001374700.2 → NP_001361629.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC090489
      Consensus CDS
      CCDS88110.1
      UniProtKB/TrEMBL
      A0A1W2P7J1
      Related
      ENSMUSP00000151645.2, ENSMUST00000220227.2
      Conserved Domains (1) summary
      cd07813
      Location:89 → 227
      COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

    3. NM_001416566.1 → NP_001403495.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090489

    4. NM_001416567.1 → NP_001403496.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090489
      UniProtKB/TrEMBL
      A0A1W2P7G5
      Related
      ENSMUSP00000151609.2, ENSMUST00000220027.2

    RNA

    1. NR_184315.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090489

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128198965..128204849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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